J
Jianhua Yu
Researcher at City of Hope National Medical Center
Publications - 243
Citations - 15256
Jianhua Yu is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Interleukin 12 & Interleukin 21. The author has an hindex of 58, co-authored 238 publications receiving 12122 citations. Previous affiliations of Jianhua Yu include James Cancer Hospital & Ohio State University.
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Journal ArticleDOI
The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody
Don M. Benson,Courtney E. Bakan,Anjali Mishra,Craig C. Hofmeister,Yvonne A. Efebera,Brian Becknell,Robert A. Baiocchi,Jianying Zhang,Jianhua Yu,Megan K. Smith,Carli N Greenfield,Pierluigi Porcu,Steven M. Devine,Rinat Rotem-Yehudar,Gerard Lozanski,John C. Byrd,Michael A. Caligiuri +16 more
TL;DR: It is demonstrated that CT-011, a novel anti-PD-1 antibody, enhances humanNK-cell function against autologous, primary MM cells, seemingly through effects on NK-cell trafficking, immune complex formation with MM cells and cytotoxicity specifically toward PD-L1(+) MM tumor cells but not normal cells.
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MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.
Ramiro Garzon,Shujun Liu,Muller Fabbri,Zhongfa Liu,Catherine E. A. Heaphy,Elisa Callegari,Sebastian Schwind,Jiuxia Pang,Jianhua Yu,Natarajan Muthusamy,Violaine Havelange,Stefano Volinia,William Blum,Laura J. Rush,Danilo Perrotti,Michael Andreeff,Clara D. Bloomfield,John C. Byrd,Kenneth Chan,Lai-Chu Wu,Carlo M. Croce,Guido Marcucci +21 more
TL;DR: Novel functional links between miRNAs and aberrant DNA hypermethylation in acute myeloid leukemia and suggest a potentially therapeutic use of synthetic miR-29b oligonucleotides as effective hypomethylating compounds are provided.
Journal ArticleDOI
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
Shu-Hao Hsu,Bo Wang,Janaiah Kota,Jianhua Yu,Stefan Costinean,Huban Kutay,Lianbo Yu,Shoumei Bai,Shoumei Bai,Krista M. D. La Perle,Raghu R. Chivukula,Hsiaoyin Mao,Min Wei,K. Reed Clark,K. Reed Clark,Jerry R. Mendell,Jerry R. Mendell,Michael A. Caligiuri,Samson T. Jacob,Joshua T. Mendell,Kalpana Ghoshal +20 more
TL;DR: It is demonstrated that deletion of mouse Mir122 resulted in hepatosteatosis, hepatitis, and the development of tumors resembling HCC, demonstrating critical functions for miR-122 in the maintenance of liver homeostasis and have important therapeutic implications, including the potential utility of mi R-122 delivery for selected patients with HCC and the need for careful monitoring of patients receiving miR -122 inhibition therapy for HCV.
Journal ArticleDOI
The Broad Spectrum of Human Natural Killer Cell Diversity.
TL;DR: The recent discoveries of tissue-resident NK cell developmental intermediates, non-NK innate lymphoid cells, and the capacity for NK cells to adapt and differentiate into long-lived memory cells has added further complexity to this field.
Journal ArticleDOI
CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma
Jianhong Chu,Youcai Deng,Don M. Benson,Shun He,Tiffany Hughes,Jianying Zhang,Yong Peng,Hsiaoyin Mao,Ling Yi,Kalpana Ghoshal,Xiaoming He,Steven M. Devine,Xiaoliu Zhang,Michael A. Caligiuri,Craig C. Hofmeister,Jianhua Yu +15 more
TL;DR: CS1 represents a viable target for CAR-expressing immune cells, and autologous or allogeneic transplantation of CS1-specific CAR NK cells may be a promising strategy to treat MM.