J
Jichan Jang
Researcher at Institut Pasteur Korea
Publications - 17
Citations - 1089
Jichan Jang is an academic researcher from Institut Pasteur Korea. The author has contributed to research in topics: Mycobacterium tuberculosis & Medicine. The author has an hindex of 8, co-authored 9 publications receiving 916 citations. Previous affiliations of Jichan Jang include Gyeongsang National University & Pasteur Institute.
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Journal ArticleDOI
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
Kevin Pethe,Pablo Bifani,Jichan Jang,Sunhee Kang,Seijin Park,Sujin Ahn,Jan Jiricek,Ju-Young Jung,Hee Kyoung Jeon,Jonathan Cechetto,Thierry Christophe,Honggun Lee,Marie Kempf,Mary Jackson,Anne J. Lenaerts,Hang Ohuong Pham,Victoria Jones,Min Jung Seo,Young-Mi Kim,Mooyoung Seo,Jeong Jea Seo,Dongsik Park,Yoonae Ko,Inhee Choi,Ryangyeo Kim,Se Yeon Kim,Seungbin Lim,Seung-Ae Yim,Jiyoun Nam,Hwankyu Kang,Haejin Kwon,Chun-Taek Oh,Yoojin Cho,Yunhee Jang,Junghwan Kim,Adeline C. Y. Chua,Bee Huat Tan,Mahesh Nanjundappa,Srinivasa P. S. Rao,Whitney Barnes,René Wintjens,John R. Walker,Sylvie Alonso,Saeyeon Lee,Jungjun Kim,Soohyun Oh,Taegwon Oh,Ulf Nehrbass,Sung-Jun Han,Zaesung No,Jinhwa Lee,Priscille Brodin,Sang Nae Cho,Kiyean Nam,Jaeseung Kim +54 more
TL;DR: The optimized IPA compound Q203 inhibited the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in the low nanomolar range and was efficacious in a mouse model of tuberculosis at a dose less than 1 mg per kg body weight, which highlights the potency of this compound.
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High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling
Priscille Brodin,Priscille Brodin,Yannick Poquet,Yannick Poquet,Florence Levillain,Florence Levillain,Isabelle Peguillet,Gerald Larrouy-Maumus,Gerald Larrouy-Maumus,Martine Gilleron,Martine Gilleron,Fanny Anne Ewann,Thierry Christophe,Denis Philippe Cedric Fenistein,Jichan Jang,Mi-Seon Jang,Seijin Park,Jean Rauzier,Jean-Philippe Carralot,Rachel Shrimpton,Auguste Genovesio,Jesús Gonzalo-Asensio,Germain Puzo,Germain Puzo,Carlos Martin,Roland Brosch,Graham R. Stewart,Brigitte Gicquel,Olivier Neyrolles,Olivier Neyrolles,Olivier Neyrolles +30 more
TL;DR: A high throughput phenotypic cell-based assay enabling individual sub-cellular analysis of over 11,000 Mycobacterium tuberculosis mutants suggests that glycolipids indeed play a critical role in the early intracellular fate of the tubercle bacillus.
Journal ArticleDOI
Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis
Jun Zheng,Eric J. Rubin,Pablo Bifani,Vanessa Mathys,Vivian Lim,Melvin Au,Jichan Jang,Jiyoun Nam,Thomas Dick,John R. Walker,Kevin Pethe,Luis R. Camacho +11 more
TL;DR: It is reported that PAS is a prodrug targeting dihydrofolate reductase (DHFR) through an unusual and novel mechanism of action, and it is revealed that a metabolite of PAS inhibits DHFR in the folate pathway.
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Lead Optimization of a Novel Series of Imidazo[1,2-a]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti-tuberculosis Agent
Sunhee Kang,Ryang Yeo Kim,Min Jung Seo,Saeyeon Lee,Young-Mi Kim,Mooyoung Seo,Jeong Jea Seo,Yoonae Ko,Inhee Choi,Jichan Jang,Jiyoun Nam,Seijin Park,Hwankyu Kang,Hyungjun Kim,Jungjun Kim,Sujin Ahn,Kevin Pethe,Kiyean Nam,Zaesung No,Jaeseung Kim +19 more
TL;DR: It is found that the amide linker with IPA core is very important for activity against Mycobacterium tuberculosis H37Rv and the optimized IPAs 49 and 50 showed not only excellent oral bioavailability but also displayed significant colony-forming unit (CFU) reduction in mouse lung.
Journal ArticleDOI
The balance of apoptotic and necrotic cell death in Mycobacterium tuberculosis infected macrophages is not dependent on bacterial virulence.
Rachel E. Butler,Priscille Brodin,Jichan Jang,Mi-Seon Jang,Brian D. Robertson,Brigitte Gicquel,Graham R. Stewart +6 more
TL;DR: It is shown that macrophage necrosis and apoptosis are independently regulated during M. tuberculosis infection of macrophages and that bacterial virulence influences the dynamics of caspase activation and the total level of cytotoxicity.