P
Priscille Brodin
Researcher at Pasteur Institute
Publications - 152
Citations - 13507
Priscille Brodin is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 48, co-authored 145 publications receiving 12251 citations. Previous affiliations of Priscille Brodin include university of lille & École Normale Supérieure.
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Journal ArticleDOI
A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
TL;DR: The main determinants required for Tat translocation within this sequence are delineated by synthesizing several peptides covering the Tat domain from residues 37 to 60 and the domain extending from amino acid 37 to 47, which corresponds to the α-helix structure, is not required for cellular uptake and for nuclear translocation.
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A new evolutionary scenario for the Mycobacterium tuberculosis complex
Roland Brosch,Stephen V. Gordon,M. Marmiesse,Priscille Brodin,Carmen Buchrieser,Karin Eiglmeier,Thierry Garnier,C. Gutierrez,Glyn Hewinson,Kristin Kremer,Linda M. Parsons,Alexander S. Pym,Sofía Samper,D. van Soolingen,Stewart T. Cole +14 more
TL;DR: The distribution of 20 variable regions resulting from insertion-deletion events in the genomes of the tubercle bacilli has been evaluated and contradict the often-presented hypothesis that M. tuberculosis, the etiological agent of human tuberculosis evolved from M. bovis, the agent of bovine disease.
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Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti.
TL;DR: A genetic lesion is described that contributes to safety and opens new avenues for vaccine development and resulted in a marked change in colonial morphology towards that of virulent tubercle bacilli.
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Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
Vadim Makarov,Giulia Manina,Katarína Mikušová,Ute Möllmann,O. B. Ryabova,Brigitte Saint-Joanis,Neeraj Dhar,Maria Rosalia Pasca,Silvia Buroni,Anna Paola Lucarelli,Anna Milano,Edda De Rossi,Martina Belanova,Adela Bobovská,Petronela Dianišková,Jana Korduláková,Claudia Sala,Elizabeth Fullam,Patricia Schneider,John D. McKinney,Priscille Brodin,Thierry Christophe,Simon J. Waddell,Philip D. Butcher,Jakob Albrethsen,Ida Rosenkrands,Roland Brosch,Vrinda Nandi,Sowmya Bharath,Sheshagiri Gaonkar,Radha Shandil,V. Balasubramanian,Tanjore S. Balganesh,Sandeep Tyagi,Jacques H. Grosset,Giovanna Riccardi,Stewart T. Cole +36 more
TL;DR: The synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB are described.
Journal ArticleDOI
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis.
Alexander S. Pym,Alexander S. Pym,Priscille Brodin,Laleh Majlessi,Roland Brosch,Caroline Demangel,Ann Williams,Karen E. Griffiths,Gilles Marchal,Claude Leclerc,Stewart T. Cole +10 more
TL;DR: Mice and guinea pigs vaccinated with the recombinant strain BCG::RD1-2F9 were better protected against challenge with M. tuberculosis, showing less severe pathology and reduced dissemination of the pathogen, as compared with control animals immunized with BCG alone.