J
Jie Ran
Researcher at Shandong Normal University
Publications - 30
Citations - 731
Jie Ran is an academic researcher from Shandong Normal University. The author has contributed to research in topics: Cilium & Ciliogenesis. The author has an hindex of 14, co-authored 25 publications receiving 557 citations. Previous affiliations of Jie Ran include Nankai University.
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Journal ArticleDOI
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.
TL;DR: Evidence is provided that HDAC6-mediated deacetylation of α-tubulin and cortactin is critical for its induction of ciliary disassembly, and the importance of reversible acetylation in regulating ciliary homeostasis is underscored.
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CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation
TL;DR: It is demonstrated that cylindromatosis (CYLD) regulates spindle orientation via its dual functions as a microtubule-associated protein and deubiquitinase, and uncovered CYLD as an important player in the orientation of the mitotic spindle and cell division.
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CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6
Yunfan Yang,Jie Ran,Min Liu,Dengwen Li,Yuanyuan Li,Xingjuan Shi,Dan Meng,Junmin Pan,Guangshuo Ou,Ritu Aneja,Shao Cong Sun,Jun Zhou +11 more
TL;DR: It is shown that cylindromatosis (CYLD), a tumor suppressor protein harboring deubiquitinase activity, plays a critical role in the assembly of both primary and motile cilia in multiple organs and is identified as a crucial regulator of this process.
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HDAC6 Deacetylase Activity Is Critical for Lipopolysaccharide-Induced Activation of Macrophages
Bing Yan,Songbo Xie,Zhu Liu,Jie Ran,Yuanyuan Li,Jian Wang,Yang Yang,Jun Zhou,Dengwen Li,Min Liu +9 more
TL;DR: In this article, the authors identify a role for histone deacetylse 6 (HDAC6) in lipopolysaccharide (LPS)-induced macrophage activation and show that suppression of HDAC6 activity significantly restrains LPS-induced activation of macrophages and production of pro-inflammatory cytokines.
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Targeted inhibition of histone deacetylase 6 in inflammatory diseases.
TL;DR: Recent findings highlighting the critical roles of HDAC6 in a variety of inflammatory diseases are reviewed, and the therapeutic potential ofHDAC6 inhibitors in these settings are discussed.