Jie Wu

TL;DR: It is found that AgNPs could inhibit the viability of AML cells including the isolates from AML patients, and supported the model that both generation of ROS and release of silver ions played critical roles in the AgnPs-induced cytotoxic effect against AMl cells.

TL;DR: It is suggested that autophagy is involved in the cytotoxicity of PVP-coated AgNPs in normal hematopoietic cells, and the inhibition of autophagic flux is a novel and potent strategy to protect normal heMatopoetic cells upon treatment with AgNNP.

TL;DR: GAS2 was up-regulated in CML cells including CD34+ progenitor cells compared to their normal counterparts and the inhibition of GAS2 impairs the growth of Cml cells, which indicates GAS1 is a novel regulator of C ML cells and a potential therapeutic target of this disease.

TL;DR: It is demonstrated that ZFX is aberrantly expressed in multiple human leukemic cells and it modulates the growth and drug response of leukeMIC cells partially via B4GALT1, which suggests that Z FX is a new regulator of leukedmic cells.

TL;DR: The findings indicate that Nr-CWS could suppress the lung metastasis induced by B16F10 melanoma cells, which may be exerted through its effect on NK cells by promoting NK cell terminal differentiation (CD27lowCD11bhigh), and up-regulating the production of cytokines and cytotoxic molecules.