Journal ArticleDOI
Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions
Dawei Guo,Lingying Zhu,Zhihai Huang,Haixia Zhou,Yue Ge,Wenjuan Ma,Jie Wu,Xiuyan Zhang,Xuefeng Zhou,Yu Zhang,Yun Zhao,Ning Gu +11 more
TLDR
It is found that AgNPs could inhibit the viability of AML cells including the isolates from AML patients, and supported the model that both generation of ROS and release of silver ions played critical roles in the AgnPs-induced cytotoxic effect against AMl cells.About:
This article is published in Biomaterials.The article was published on 2013-10-01. It has received 243 citations till now. The article focuses on the topics: Silver nanoparticle & Reactive oxygen species.read more
Citations
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Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches
TL;DR: This review extensively discusses the multifunctional bio-applications of AgNPs; for example, as antibacterial, antifungal, antiviral,Anti-inflammatory, anti-angiogenic, and anti-cancer agents, and the mechanism of the anti- cancer activity of Ag NPs.
Journal ArticleDOI
Silver nanoparticles: synthesis, properties, and therapeutic applications.
TL;DR: Methods of synthesizing AgNPs are introduced and their physicochemical, localized surface plasmon resonance (LSPR) and toxicity properties are discussed, highlighting the newly emerging applications ofAgNPs as antiviral agents, photosensitizer and/or radiosensitizers, and anticancer therapeutic agents.
Journal ArticleDOI
Silver Nanoparticles: Therapeutical Uses, Toxicity, and Safety Issues
Carolina Alves dos Santos,Marcelo Martins Seckler,Avinash P. Ingle,Indarchand Gupta,Indarchand Gupta,Stefania Galdiero,Massimiliano Galdiero,Aniket Gade,Mahendra Rai +8 more
TL;DR: This review aims to discuss AgNPs applied in biomedicine and as promising field for insertion and development of new compounds related to medical and pharmacy technology and addresses drug delivery, toxicity issues, and the safety rules concerning biomedical applications of silver nanoparticles.
Journal ArticleDOI
Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death.
TL;DR: An assessment of signaling pathways that are involved in the nanoparticle-induced oxidative stress and propose possible strategies to circumvent nanotoxicity are provided.
Journal ArticleDOI
The dissolution and biological effects of silver nanoparticles in biological media
Kateryna Loza,Jörg Diendorf,Christina Sengstock,Luisa Ruiz-González,José M. González-Calbet,María Vallet-Regí,Manfred Köller,Matthias Epple +7 more
TL;DR: The dissolution effects were confirmed by cell culture experiments (human mesenchymal stem cells and neutrophil granulocytes) where silver nanoparticles that were stored under argon had a clearly lower cytotoxicity than those stored under air.
References
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Journal ArticleDOI
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Dominique Bonnet,John E. Dick +1 more
TL;DR: It is demonstrated that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) — termed the SCID leukemia-initiating cell, or SL-IC — possesses the differentiate and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell.
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Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
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Oxidative DNA damage: mechanisms, mutation, and disease
TL;DR: This review critically addresses the extent to which the in vitro significance of oxidative DNA damage has relevance for the pathogenesis of disease, drawing attention to the multiplicity of proteins with repair activities along with a number of poorly considered effects of damage.
Journal ArticleDOI
Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species.
C. Carlson,Saber M. Hussain,Amanda M. Schrand,Laura K. Braydich-Stolle,K. L. Hess,R. L. Jones,John J. Schlager +6 more
TL;DR: A size-dependent toxicity was produced by silver nanoparticles, and one predominant mechanism of toxicity was found to be largely mediated through oxidative stress.
Journal ArticleDOI
Ion Release Kinetics and Particle Persistence in Aqueous Nano-Silver Colloids
Jingyu Liu,Robert H. Hurt +1 more
TL;DR: An empirical kinetic law is proposed that reproduces the observed effects of dissolution time, pH, humic/fulvic acid content, and temperature observed here in the low range of nanosilver concentration most relevant for the environment.