J
Jiegou Xu
Researcher at Anhui Medical University
Publications - 32
Citations - 702
Jiegou Xu is an academic researcher from Anhui Medical University. The author has contributed to research in topics: Medicine & Lung. The author has an hindex of 13, co-authored 24 publications receiving 582 citations. Previous affiliations of Jiegou Xu include Nagoya City University.
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Journal ArticleDOI
Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats
Jiegou Xu,Mitsuru Futakuchi,Hideo Shimizu,David B. Alexander,Kazuyoshi Yanagihara,Katsumi Fukamachi,Masumi Suzui,Jun Kanno,Akihiko Hirose,Akio Ogata,Yoshimitsu Sakamoto,Dai Nakae,Toyonori Omori,Hiroyuki Tsuda +13 more
TL;DR: In this article, the authors investigated whether carbon nanotubes administered into the lung through the trachea induce mesothelial lesions and found that the fibers were also found in the cell pellets of the pleural cavity lavage, mostly in macrophages.
Journal ArticleDOI
Cancer prevention by bovine lactoferrin: from animal studies to human trial
Hiroyuki Tsuda,Takahiro Kozu,Gen Iinuma,Yasuo Ohashi,Yutaka Saito,Daizo Saito,Takayuki Akasu,David B. Alexander,Mitsuru Futakuchi,Katsumi Fukamachi,Jiegou Xu,Tadao Kakizoe,Masaaki Iigo +12 more
TL;DR: Work which established bLF as an anti-carcinogenic agent in laboratory animals and the results of a clinical trial which demonstrated thatbLF can reduce the risk of colon carcinogenesis in humans are reviewed.
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Anticarcinogenesis pathways activated by bovine lactoferrin in the murine small intestine
Masaaki Iigo,David B. Alexander,Ne Long,Jiegou Xu,Katsumi Fukamachi,Mitsuru Futakuchi,Mitsunori Takase,Hiroyuki Tsuda +7 more
TL;DR: Results indicate that orally administered bLF can induce expression of IFNgamma and caspase-1 in the small intestine and show that ingested bLf is able to activate more than a single effector pathway.
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Size‐ and shape‐dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes
Jiegou Xu,David B. Alexander,Mitsuru Futakuchi,Takamasa Numano,Katsumi Fukamachi,Masumi Suzui,Toyonori Omori,Jun Kanno,Akihiko Hirose,Hiroyuki Tsuda +9 more
TL;DR: Results suggest that MWCNT‐L has higher risk of causing asbestos‐like pleural lesions relevant to mesothelioma development.
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Involvement of macrophage inflammatory protein 1α (MIP1α) in promotion of rat lung and mammary carcinogenic activity of nanoscale titanium dioxide particles administered by intra-pulmonary spraying
Jiegou Xu,Mitsuru Futakuchi,Masaaki Iigo,Katsumi Fukamachi,David B. Alexander,Hideo Shimizu,Yuto Sakai,Seiko Tamano,Fumio Furukawa,Tadashi Uchino,Hiroshi Tokunaga,Tetsuji Nishimura,Akihiko Hirose,Jun Kanno,Hiroyuki Tsuda +14 more
TL;DR: The data indicate that secreted MIP1alpha from TiO(2)-laden alveolar macrophages can cause cell proliferation in the alveoli and mammary gland and suggest that TiO (2) tumor promotion is mediated by MIP 1alpha acting locally in theAlveoliand distantly in the mammary glands after transport via the circulation.