Jiliang Zhou

TL;DR: IPC induced autophagy in renal tubular cells in mice and suppressed subsequent renal ischemia-reperfusion injury (IRI), suggesting that IPC may protect kidneys by activating mitophagy, and in vitro IPC increased mitophagosome formation and promoted the clearance of damaged mitochondria during subsequent CCCP treatment.

TL;DR: In this article, the role of NEAT1 in vascular smooth muscle cells (VSMCs) phenotypic modulation is unknown, but it was shown that NEAT expression was induced in VSMCs during phenotypeic switching in vivo and in vitro.

TL;DR: Biotinylated knockin alleles of seven key cardiac TFs are used to sensitively and reproducibly map their genome-wide occupancy in the fetal and adult mouse heart, providing insight into the cardiac transcriptional regulatory network.

TL;DR: An unexpected role of the lncRNA NEAT1 is demonstrated in regulating phenotypic switching by repressing SM-contractile gene expression through an epigenetic regulatory mechanism and suggests that NEAT 1 is a novel therapeutic target for treating occlusive vascular diseases in humans.

TL;DR: A role for neddylation is demonstrated in heart development and, more specifically, in the maturation of ventricular chambers and the NEDD8 substrate Cullin 7 is identified as a regulator of Hippo-YAP signaling.