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William T. Pu
Researcher at Boston Children's Hospital
Publications - 233
Citations - 21750
William T. Pu is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Transcription factor. The author has an hindex of 73, co-authored 212 publications receiving 18259 citations. Previous affiliations of William T. Pu include Duke University & Harvard University.
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Journal ArticleDOI
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
Elisabeth M. Zeisberg,Oleg Tarnavski,Michael Zeisberg,Adam L. Dorfman,Julie R. McMullen,Erika Gustafsson,Anil Chandraker,Xueli Yuan,William T. Pu,Anita B. Roberts,Eric G. Neilson,Mohamed H. Sayegh,Seigo Izumo,Raghu Kalluri +13 more
TL;DR: It is shown that cardiac fibrosis is associated with the emergence of fibroblasts originating from endothelial cells, suggesting an endothelial-mesenchymal transition (EndMT) similar to events that occur during formation of the atrioventricular cushion in the embryonic heart.
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Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
Bin Zhou,Qing Ma,Qing Ma,Satish Rajagopal,Satish Rajagopal,Sean M. Wu,Ibrahim J. Domian,José Rivera-Feliciano,Dawei Jiang,Alexander von Gise,Alexander von Gise,Alexander von Gise,Sadakatsu Ikeda,Sadakatsu Ikeda,Kenneth R. Chien,William T. Pu,William T. Pu +16 more
TL;DR: A novel cardiogenic precursor marked by expression of the transcription factor Wt1 and located within the epicardium—an epithelial sheet overlying the heart is identified and identified as previously unrecognized cardiomyocyte progenitors.
Journal ArticleDOI
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
Gang Wang,Megan L. McCain,Luhan Yang,Aibin He,Francesco S. Pasqualini,Ashutosh Agarwal,Hongyan Yuan,Dawei Jiang,Donghui Zhang,Lior Zangi,Judith Geva,Amy E. Roberts,Qing Ma,Jian-Ping Ding,Jinghai Chen,Da-Zhi Wang,Kai Li,Jiwu Wang,Ronald J.A. Wanders,Wim Kulik,Frédéric M. Vaz,Michael A. Laflamme,Charles E. Murry,Kenneth R. Chien,Richard I. Kelley,George M. Church,Kevin Kit Parker,William T. Pu +27 more
TL;DR: This study combined patient-derived and genetically engineered induced pluripotent stem cells (iPSCs) with tissue engineering to elucidate the pathophysiology underlying the cardiomyopathy of Barth syndrome, a mitochondrial disorder caused by mutation of the gene encoding tafazzin (TAZ).
Journal ArticleDOI
Altered microRNA expression in human heart disease
Sadakatsu Ikeda,Sek Won Kong,Jun Lu,Egbert Bisping,Hao Zhang,Paul D. Allen,Todd R. Golub,Todd R. Golub,Burkert Pieske,William T. Pu +9 more
TL;DR: The data show that expression of many microRNAs is altered in heart disease and that different types of heart disease are associated with distinct changes in microRNA expression.
Journal ArticleDOI
De novo cardiomyocytes from within the activated adult heart after injury
Nicola Smart,Sveva Bollini,Karina N. Dubé,Joaquim M. Vieira,Bin Zhou,Bin Zhou,Bin Zhou,Sean M. Davidson,Derek M. Yellon,Johannes Riegler,Anthony N. Price,Mark F. Lythgoe,William T. Pu,William T. Pu,Paul R. Riley +14 more
TL;DR: It is demonstrated in mice that the adult heart contains a resident stem or progenitor cell population, which has the potential to contribute bona fide terminally differentiated cardiomyocytes after myocardial infarction and is shown to structurally and functionally integrate with resident muscle.