J
Jillian L. Astarita
Researcher at Genentech
Publications - 23
Citations - 6069
Jillian L. Astarita is an academic researcher from Genentech. The author has contributed to research in topics: Stromal cell & Podoplanin. The author has an hindex of 14, co-authored 22 publications receiving 4075 citations. Previous affiliations of Jillian L. Astarita include Harvard University & National Institutes of Health.
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Journal ArticleDOI
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
Sanjeev Mariathasan,Shannon J. Turley,Dorothee Nickles,Alessandra Castiglioni,Kobe C. Yuen,Yulei Wang,Edward E. Kadel,Hartmut Koeppen,Jillian L. Astarita,Rafael Cubas,Suchit Jhunjhunwala,Romain Banchereau,Yagai Yang,Yinghui Guan,Cecile Chalouni,James Ziai,Yasin Senbabaoglu,Stephen Santoro,Daniel Sheinson,Jeffrey Hung,Jennifer M. Giltnane,Andrew A. Pierce,Kathryn Mesh,Steve Lianoglou,Johannes Riegler,Richard A.D. Carano,Pontus Eriksson,Mattias Höglund,Loan Somarriba,Daniel L. Halligan,Michiel S. van der Heijden,Yohann Loriot,Jonathan E. Rosenberg,Lawrence Fong,Ira Mellman,Daniel S. Chen,Marjorie C. Green,Christina Louise Derleth,Gregg Fine,Priti S. Hegde,Richard Bourgon,Thomas Powles +41 more
TL;DR: Tumours from a large cohort of patients with metastatic urothelial cancer who were treated with an anti-PD-L1 agent were examined and major determinants of clinical outcome were identified and suggested that TGFβ shapes the tumour microenvironment to restrain anti-tumour immunity by restricting T-cell infiltration.
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Immunological hallmarks of stromal cells in the tumour microenvironment
TL;DR: Evidence thatStromal determinants interact with leukocytes and influence antitumour immunity is discussed, with emphasis on the immunological attributes of stromal cells that may foster their protumorigenic function.
Journal ArticleDOI
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
Deepali Malhotra,Anne L. Fletcher,Jillian L. Astarita,Veronika Lukacs-Kornek,Prakriti Tayalia,Santiago F. Gonzalez,Kutlu G. Elpek,Sook Kyung Chang,Konstantin Knoblich,Martin E. Hemler,Michael B. Brenner,Michael C. Carroll,David J. Mooney,Shannon J. Turley +13 more
TL;DR: Comparison transcriptomic analyses of mouse LNSC subsets demonstrated the expression of important immune mediators, growth factors and previously unknown structural components in hematopoietic and stromal subsets, suggesting a complex web of crosstalk.
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
Deepali Malhotra,Anne L. Fletcher,Jillian L. Astarita,Veronika Lukacs-Kornek,Prakriti Tayalia,Santiago F. Gonzalez,Kutlu G. Elpek,Sook Kyung Chang,Konstantin Knoblich,Martin E. Hemler,Michael B. Brenner,Michael C. Carroll,David J. Mooney,Shannon J. Turley +13 more
TL;DR: In this article, comparative transcriptomic analyses of mouse lymph node stromal cells (LNSCs) subsets demonstrated the expression of important immune mediators and self-tolerance.
Journal ArticleDOI
Podoplanin: emerging functions in development, the immune system, and cancer
TL;DR: A comprehensive overview of the diverse roles of PDPN in development, immunology, and cancer is provided.