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Kutlu G. Elpek
Researcher at Harvard University
Publications - 60
Citations - 7556
Kutlu G. Elpek is an academic researcher from Harvard University. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 29, co-authored 56 publications receiving 6605 citations. Previous affiliations of Kutlu G. Elpek include University of Louisville.
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Journal ArticleDOI
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
Emmanuel L. Gautier,Tal Shay,Tal Shay,Jennifer Miller,Melanie Greter,Claudia Jakubzick,Stoyan Ivanov,Julie Helft,Andrew Chow,Kutlu G. Elpek,Simon Gordonov,Amin R. Mazloom,Avi Ma'ayan,Wei-Jen Chua,Ted H. Hansen,Shannon J. Turley,Miriam Merad,Gwendalyn J. Randolph +17 more
TL;DR: It is identified how well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages and how these transcripts and the proteins they encode facilitated distinguishing macrophage from dendritic cells.
Journal ArticleDOI
The Immunological Genome Project: networks of gene expression in immune cells
Tracy Heng,Michio W. Painter,Kutlu G. Elpek,Veronika Lukacs-Kornek,Nora Mauermann,Shannon J. Turley,Daphne Koller,Francis S. Kim,Amy J. Wagers,Natasha Asinovski,Scott Davis,Marlys S. Fassett,Markus Feuerer,Daniel H.D. Gray,Sokol Haxhinasto,Jonathan A. Hill,Gordon Hyatt,Catherine Laplace,Kristen Leatherbee,Diane Mathis,Christophe Benoist,Radu Jianu,David H. Laidlaw,J Adam Best,Jamie Knell,Ananda W. Goldrath,Jessica Jarjoura,Joseph C. Sun,Yanan Zhu,Lewis L. Lanier,Ayla Ergun,Zheng Li,James J. Collins,Susan A. Shinton,Richard R. Hardy,Randall Friedline,Katelyn Sylvia,Joonsoo Kang +37 more
TL;DR: The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immune cells.
Journal ArticleDOI
Deciphering the transcriptional network of the dendritic cell lineage
Jennifer Miller,Brian D. Brown,Tal Shay,Emmanuel L. Gautier,Emmanuel L. Gautier,Vladimir Jojic,Vladimir Jojic,Ariella Cohain,Gaurav Pandey,Marylene Leboeuf,Kutlu G. Elpek,Julie Helft,Daigo Hashimoto,Andrew Chow,Andrew Chow,Jeremy Price,Melanie Greter,Melanie Greter,Milena Bogunovic,Angelique Bellemare-Pelletier,Paul S. Frenette,Gwendalyn J. Randolph,Gwendalyn J. Randolph,Shannon J. Turley,Miriam Merad +24 more
TL;DR: A transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens is identified and predicted regulators of DC functional diversity in tissues are predicted.
Journal ArticleDOI
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
Deepali Malhotra,Anne L. Fletcher,Jillian L. Astarita,Veronika Lukacs-Kornek,Prakriti Tayalia,Santiago F. Gonzalez,Kutlu G. Elpek,Sook Kyung Chang,Konstantin Knoblich,Martin E. Hemler,Michael B. Brenner,Michael C. Carroll,David J. Mooney,Shannon J. Turley +13 more
TL;DR: Comparison transcriptomic analyses of mouse LNSC subsets demonstrated the expression of important immune mediators, growth factors and previously unknown structural components in hematopoietic and stromal subsets, suggesting a complex web of crosstalk.
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
Deepali Malhotra,Anne L. Fletcher,Jillian L. Astarita,Veronika Lukacs-Kornek,Prakriti Tayalia,Santiago F. Gonzalez,Kutlu G. Elpek,Sook Kyung Chang,Konstantin Knoblich,Martin E. Hemler,Michael B. Brenner,Michael C. Carroll,David J. Mooney,Shannon J. Turley +13 more
TL;DR: In this article, comparative transcriptomic analyses of mouse lymph node stromal cells (LNSCs) subsets demonstrated the expression of important immune mediators and self-tolerance.