J
Johannes Riegler
Researcher at Stanford University
Publications - 38
Citations - 6062
Johannes Riegler is an academic researcher from Stanford University. The author has contributed to research in topics: Stem cell & Transplantation. The author has an hindex of 24, co-authored 37 publications receiving 4215 citations. Previous affiliations of Johannes Riegler include Cardiovascular Institute of the South & Ruhr University Bochum.
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Journal ArticleDOI
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
Sanjeev Mariathasan,Shannon J. Turley,Dorothee Nickles,Alessandra Castiglioni,Kobe C. Yuen,Yulei Wang,Edward E. Kadel,Hartmut Koeppen,Jillian L. Astarita,Rafael Cubas,Suchit Jhunjhunwala,Romain Banchereau,Yagai Yang,Yinghui Guan,Cecile Chalouni,James Ziai,Yasin Senbabaoglu,Stephen Santoro,Daniel Sheinson,Jeffrey Hung,Jennifer M. Giltnane,Andrew A. Pierce,Kathryn Mesh,Steve Lianoglou,Johannes Riegler,Richard A.D. Carano,Pontus Eriksson,Mattias Höglund,Loan Somarriba,Daniel L. Halligan,Michiel S. van der Heijden,Yohann Loriot,Jonathan E. Rosenberg,Lawrence Fong,Ira Mellman,Daniel S. Chen,Marjorie C. Green,Christina Louise Derleth,Gregg Fine,Priti S. Hegde,Richard Bourgon,Thomas Powles +41 more
TL;DR: Tumours from a large cohort of patients with metastatic urothelial cancer who were treated with an anti-PD-L1 agent were examined and major determinants of clinical outcome were identified and suggested that TGFβ shapes the tumour microenvironment to restrain anti-tumour immunity by restricting T-cell infiltration.
Journal ArticleDOI
De novo cardiomyocytes from within the activated adult heart after injury
Nicola Smart,Sveva Bollini,Karina N. Dubé,Joaquim M. Vieira,Bin Zhou,Bin Zhou,Bin Zhou,Sean M. Davidson,Derek M. Yellon,Johannes Riegler,Anthony N. Price,Mark F. Lythgoe,William T. Pu,William T. Pu,Paul R. Riley +14 more
TL;DR: It is demonstrated in mice that the adult heart contains a resident stem or progenitor cell population, which has the potential to contribute bona fide terminally differentiated cardiomyocytes after myocardial infarction and is shown to structurally and functionally integrate with resident muscle.
Journal ArticleDOI
Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.
Malte Tiburcy,James E. Hudson,Paul Balfanz,Susanne F. Schlick,Tim Meyer,Mei-Ling Chang Liao,Elif Levent,Farah Raad,Sebastian Zeidler,Edgar Wingender,Johannes Riegler,Mouer Wang,Joseph D. Gold,Izhak Kehat,Erich Wettwer,Ursula Ravens,Pieterjan Dierickx,Linda W. van Laake,Marie-José Goumans,Sara Khadjeh,Karl Toischer,Gerd Hasenfuss,Larry A. Couture,Andreas Unger,Wolfgang A. Linke,Toshiyuki Araki,Benjamin G. Neel,Gordon Keller,Lior Gepstein,Joseph C. Wu,Wolfram-Hubertus Zimmermann +30 more
TL;DR: A proof-of-concept for a universally applicable technology for the engineering of macroscale human myocardium for disease modeling and heart repair from embryonic and induced pluripotent stem cell–derived cardiomyocytes under defined, serum-free conditions is provided.
Journal ArticleDOI
Stem cell imaging: from bench to bedside
TL;DR: How in vivo molecular imaging has helped identify barriers to clinical translation and potential strategies that may contribute to successful transplantation and improved outcomes is discussed, with a focus on cardiovascular and neurological diseases.
Journal ArticleDOI
A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration
Giorgia Totonelli,Panagiotis Maghsoudlou,Massimo Garriboli,Johannes Riegler,Giuseppe Orlando,Alan J. Burns,Neil J. Sebire,Virpi V. Smith,Jonathan Fishman,Marco Ghionzoli,Mark Turmaine,Martin A. Birchall,Anthony Atala,Shay Soker,Mark F. Lythgoe,Alexander M. Seifalian,Agostino Pierro,Simon Eaton,Paolo De Coppi +18 more
TL;DR: Using a detergent-enzymatic treatment (DET), a new protocol is optimized in rats that creates a natural intestinal scaffold, as a base for developing functional intestinal tissue, to strengthen the idea that matrices obtained using DET may represent a valid support for intestinal regeneration.