J
Jonathan E. Rosenberg
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 468
Citations - 31038
Jonathan E. Rosenberg is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Bladder cancer & Metastatic Urothelial Carcinoma. The author has an hindex of 59, co-authored 406 publications receiving 22459 citations. Previous affiliations of Jonathan E. Rosenberg include Cornell University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
Jonathan E. Rosenberg,Jean H. Hoffman-Censits,Thomas Powles,Michiel S. van der Heijden,Arjun Vasant Balar,Andrea Necchi,Nancy A. Dawson,Peter H. O'Donnell,Ani Balmanoukian,Yohann Loriot,Sandy Srinivas,Margitta Retz,Petros Grivas,Richard W. Joseph,Matthew D. Galsky,Mark D. Fleming,Daniel P. Petrylak,Jose Luis Perez-Gracia,Howard A. Burris,Daniel Castellano,Christina Canil,Joaquim Bellmunt,Dean F. Bajorin,Dorothee Nickles,Richard Bourgon,Garrett M. Frampton,Na Cui,Sanjeev Mariathasan,Oyewale O. Abidoye,Gregg Fine,Robert Dreicer +30 more
TL;DR: Treatment with atezolizumab resulted in a significantly improved RECIST v1.1 response rate, compared with a historical control overall response rate of 10%, and Exploratory analyses showed The Cancer Genome Atlas (TCGA) subtypes and mutation load to be independently predictive for response to atezolediazepine.
Journal ArticleDOI
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
Sanjeev Mariathasan,Shannon J. Turley,Dorothee Nickles,Alessandra Castiglioni,Kobe C. Yuen,Yulei Wang,Edward E. Kadel,Hartmut Koeppen,Jillian L. Astarita,Rafael Cubas,Suchit Jhunjhunwala,Romain Banchereau,Yagai Yang,Yinghui Guan,Cecile Chalouni,James Ziai,Yasin Senbabaoglu,Stephen Santoro,Daniel Sheinson,Jeffrey Hung,Jennifer M. Giltnane,Andrew A. Pierce,Kathryn Mesh,Steve Lianoglou,Johannes Riegler,Richard A.D. Carano,Pontus Eriksson,Mattias Höglund,Loan Somarriba,Daniel L. Halligan,Michiel S. van der Heijden,Yohann Loriot,Jonathan E. Rosenberg,Lawrence Fong,Ira Mellman,Daniel S. Chen,Marjorie C. Green,Christina Louise Derleth,Gregg Fine,Priti S. Hegde,Richard Bourgon,Thomas Powles +41 more
TL;DR: Tumours from a large cohort of patients with metastatic urothelial cancer who were treated with an anti-PD-L1 agent were examined and major determinants of clinical outcome were identified and suggested that TGFβ shapes the tumour microenvironment to restrain anti-tumour immunity by restricting T-cell infiltration.
Journal ArticleDOI
Tumor mutational load predicts survival after immunotherapy across multiple cancer types.
Robert M. Samstein,Chung-Han Lee,Chung-Han Lee,Alexander N. Shoushtari,Alexander N. Shoushtari,Matthew D. Hellmann,Matthew D. Hellmann,Ronglai Shen,Yelena Y. Janjigian,Yelena Y. Janjigian,David Barron,Ahmet Zehir,Emmet Jordan,Antonio Omuro,Thomas Kaley,Sviatoslav M. Kendall,Robert J. Motzer,Robert J. Motzer,A. Ari Hakimi,Martin H. Voss,Martin H. Voss,Paul Russo,Jonathan E. Rosenberg,Jonathan E. Rosenberg,Gopa Iyer,Gopa Iyer,Bernard H. Bochner,Dean F. Bajorin,Dean F. Bajorin,Hikmat Al-Ahmadie,Jamie E. Chaft,Jamie E. Chaft,Charles M. Rudin,Charles M. Rudin,Gregory J. Riely,Gregory J. Riely,Shrujal S. Baxi,Shrujal S. Baxi,Alan L. Ho,Alan L. Ho,Richard J. Wong,David G. Pfister,David G. Pfister,Jedd D. Wolchok,Jedd D. Wolchok,Christopher A. Barker,Philip H. Gutin,Cameron Brennan,Viviane Tabar,Ingo K. Mellinghoff,Lisa M. DeAngelis,Charlotte E. Ariyan,Nancy Y. Lee,William D. Tap,William D. Tap,Mrinal M. Gounder,Mrinal M. Gounder,Sandra P. D'Angelo,Sandra P. D'Angelo,Leonard B. Saltz,Leonard B. Saltz,Zsofia K. Stadler,Zsofia K. Stadler,Howard I. Scher,Howard I. Scher,José Baselga,José Baselga,Pedram Razavi,Pedram Razavi,Christopher A. Klebanoff,Christopher A. Klebanoff,Rona Yaeger,Rona Yaeger,Neil H. Segal,Neil H. Segal,Geoffrey Y. Ku,Geoffrey Y. Ku,Ronald P. DeMatteo,Marc Ladanyi,Naiyer A. Rizvi,Michael F. Berger,Nadeem Riaz,David B. Solit,Timothy A. Chan,Luc G. T. Morris +84 more
TL;DR: Analysis of advanced cancer patients treated with immune-checkpoint inhibitors shows that tumor mutational burden, as assessed by targeted next-generation sequencing, predicts survival after immunotherapy across multiple cancer types.
Journal ArticleDOI
Comprehensive molecular characterization of urothelial bladder carcinoma
John N. Weinstein,Rehan Akbani,Bradley M. Broom,Wenyi Wang,Roeland Verhaak,David J. McConkey,Seth P. Lerner,Margaret Morgan,Chad J. Creighton,Carolyn L. Smith,Andrew D. Cherniack,Jaegil Kim,Chandra Sekhar Pedamallu,Michael S. Noble,Hikmat Al-Ahmadie,Victor E. Reuter,Jonathan E. Rosenberg,Dean F. Bajorin,Bernard H. Bochner,David B. Solit,Theresa M. Koppie,Brian D. Robinson,Dmitry A. Gordenin,David C. Fargo,Leszek J. Klimczak,Steven A. Roberts,Jessie Au,Peter W. Laird,Toshinori Hinoue,Nikolaus Schultz,Ricardo Ramirez,Donna E. Hansel,Katherine A. Hoadley,William Y. Kim,Jeffrey S. Damrauer,Stephen B. Baylin,Andrew J. Mungall,A. Gordon Robertson,Andy Chu,David J. Kwiatkowski,Carrie Sougnez,Kristian Cibulskis,Lee Lichtenstein,Andrey Sivachenko,Chip Stewart,Michael S. Lawrence,Gad Getz,Eric S. Lander,Stacey B. Gabrie,Lawrence A. Donehower,Scott L. Carter,Gordon Saksena,Steven E. Schumacher,Samuel S. Freeman,Joonil Jung,Ami S. Bhatt,Trevor J. Pugh,Rameen Beroukhim,Matthew Meyerson,Adrian Ally,Miruna Balasundaram,Yaron S.N. Butterfield,Noreen Dhalla,Carrie Hirst,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Tina Wong,Natasja Wye,Reanne Bowlby,Eric Chuah,Ranabir Guin,Hui Shen,Moiz S. Bootwalla,Timothy J. Triche,Phillip H. Lai,David Van Den Berg,Daniel J. Weisenberger,Saianand Balu,Tom Bodenheimer,Alan P. Hoyle,Stuart R. Jefferys,Shaowu Meng,Lisle E. Mose,Janae V. Simons,Mathew G. Soloway,Junyuan Wu,Joel S. Parker,D. Neil Hayes,Jeffrey Roach,Elizabeth Buda,Corbin D. Jones,Piotr A. Mieczkowski,Donghui Tan,Umadevi Veluvolu,Scot Waring,J. Todd Auman,Charles M. Perou,Matthew D. Wilkerson,Netty Santoso,Michael Parfenov,Xiaojia Ren,Angeliki Pantazi,Angela Hadjipanayis,Jonathan G. Seidman,Raju Kucherlapati,Semin Lee,Lixing Yang,Peter J. Park,Andrew Wei Xu,Alexei Protopopov,Jianhua Zhang,Christopher A. Bristow,Harshad S. Mahadeshwar,Sahil Seth,Xingzhi Song,Jiabin Tang,Dong Zeng,Lynda Chin,Lynda Chin,Charles C. Guo,Tod D. Casasent,Wenbin Liu,Zhenlin Ju,Thomas C. Motter,Bo Peng,Michael Ryan,Xiaoping Su,Ji Yeon Yang,Philip L. Lorenzi,Hui Yao,Nianxiang Zhang,Jiexin Zhang,Gordon B. Mills,Juok Cho,Daniel DiCara,Scott Frazer,Nils Gehlenborg,David I. Heiman,Pei Lin,Yingchun Liu,Petar Stojanov,Doug Voet,Hailei Zhang,Lihua Zou,Brady Bernard,Dick Kreisberg,Sheila Reynolds,Hector Rovira,Ilya Shmulevich,Jianjiong Gao,Anders Jacobsen,B. Arman Aksoy,Yevgeniy Antipin,Giovanni Ciriello,Gideon Dresdner,Benjamin Gross,William Lee,Boris Reva,Ronglai Shen,Rileen Sinha,S. Onur Sumer,Nils Weinhold,Marc Ladanyi,Chris Sander,Christopher C. Benz,Daniel E. Carlin,David Haussler,Sam Ng,Evano Paull,Joshua M. Stuart,Jing Zhu,Yuexin Liu,Wei Zhang,Barry S. Taylor,Tara M. Lichtenberg,Erik Zmuda,Thomas Barr,Aaron D. Black,Myra M. George,Benjamin Hanf,Carmen Helsel,Cynthia McAllister,Nilsa C. Ramirez,Nilsa C. Ramirez,Teresa R. Tabler,Stephanie Weaver,Lisa Wise,Jay Bowen,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Weiguo Jian,Sebrina A Tello,Michael Ittman,Patricia Castro,Whitney D. McClenden,Richard A. Gibbs,Charles Saller,Katherine Tarvin,Jennifer DiPiero,Jennifer Owens,Roni J. Bollag,Qiang Li,Paul M. Weinberger,Christine Czerwinski,Lori Huelsenbeck-Dill,Mary Iacocca,Nicholas J. Petrelli,Brenda Rabeno,Pat Swanson,Troy Shelton,Erin Curley,Johanna Gardner,David Mallery,Robert Penny,Nguyen Van Bang,Phan Thi Hanh,Bernard Kohl,Xuan Van Le,Bui Duc Phu,Richard Thorp,Nguyen Viet Tien,Le Quang Vinh,George E. Sandusky,Eric J. Burks,Kimberly R. Christ,Jason R. Gee,Antonia H. Holway,Alireza Moinzadeh,Andrea Sorcini,Travis Sullivan,Ilana Rebecca Garcia-Grossman,Ashley Marie Regazzi,Lori Boice,W.K. Rathmell,Leigh B. Thorne,Sheldon I. Bastacky,Benjamin Davies,Rajiv Dhir,Jeffrey R. Gingrich,Ronald L. Hrebinko,Jodi K. Maranchie,Joel B. Nelson,Anil V. Parwani,Wiam Bshara,Carmelo Gaudioso,Carl Morrison,Vina Alexopoulou,John M. S. Bartlett,Jay Engel,Sugy Kodeeswaran,Tatjana Antic,Peter H. O'Donnell,Norm D. Smith,Gary D. Steinberg,Sophie C. Egea,Carmen Gomez-Fernandez,Lynn M. Herbert,Merce Jorda,Mark S. Soloway,Allison Beaver,Suzie Carter,Payal Kapur,Cheryl M. Lewis,Yair Lotan,Jolanta Bondaruk,Bogdan Czerniak,Eila C. Skinner,Kenneth Aldape,Mark A. Jensen,Ari B. Kahn,Todd Pihl,David Pot,Deepak Srinivasan,Yunhu Wan,Martin L. Ferguson,Jean C. Zenklusen,Tanja Davidsen,John A. Demchok,Kenna R. Mills Shaw,Kenna R. Mills Shaw,Margi Sheth,Roy Tarnuzzer,Zhining Wang,Liming Yang,Carolyn M. Hutter,Bradley A. Ozenberger,Heidi J. Sofia,Greg Eley +296 more
TL;DR: Ch Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far, indicating the future possibility of targeted therapy for chromatin abnormalities.
Journal ArticleDOI
Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial.
Arjun Vasant Balar,Matthew D. Galsky,Jonathan E. Rosenberg,Thomas Powles,Daniel P. Petrylak,Joaquim Bellmunt,Yohann Loriot,Andrea Necchi,Jean H. Hoffman-Censits,Jose Luis Perez-Gracia,Nancy A. Dawson,Michiel S. van der Heijden,Robert Dreicer,Sandy Srinivas,Margitta Retz,Richard W. Joseph,Alexandra Drakaki,Ulka N. Vaishampayan,Srikala S. Sridhar,David I. Quinn,Ignacio Duran,David R. Shaffer,Bernhard J. Eigl,Petros Grivas,Evan Y. Yu,S. Li,Edward E. Kadel,Zachary Boyd,Richard Bourgon,Priti S. Hegde,Sanjeev Mariathasan,Ann Christine Thastrom,Oyewale O. Abidoye,Gregg Fine,Dean F. Bajorin +34 more
TL;DR: Atezolizumab showed encouraging durable response rates, survival, and tolerability, supporting its therapeutic use in untreated metastatic urothelial cancer.