J
Jin Mo Park
Researcher at Harvard University
Publications - 61
Citations - 6815
Jin Mo Park is an academic researcher from Harvard University. The author has contributed to research in topics: Innate immune system & Inflammation. The author has an hindex of 27, co-authored 59 publications receiving 6330 citations. Previous affiliations of Jin Mo Park include Seoul National University & University of California, San Diego.
Papers
More filters
Journal ArticleDOI
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Florian R. Greten,Lars Eckmann,Tim F. Greten,Jin Mo Park,Zhi-Wei Li,Laurence J. Egan,Laurence J. Egan,Martin F. Kagnoff,Michael Karin +8 more
TL;DR: It is shown that although deletion of IKKbeta in intestinal epithelial cells does not decrease inflammation, it leads to a dramatic decrease in tumor incidence without affecting tumor size, which is linked to increased epithelial apoptosis during tumor promotion.
Journal ArticleDOI
Macrophage Apoptosis by Anthrax Lethal Factor Through p38 MAP Kinase Inhibition
TL;DR: It is found that B. anthracis lethal factor selectively induces apoptosis of activated macrophages by cleaving the amino-terminal extension of mitogen-activated protein kinase (MAPK) kinases (MKKs) that activate p38 MAPKs.
Journal ArticleDOI
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
Li-Chung Hsu,Jin Mo Park,Kezhong Zhang,Jun-Li Luo,Shin Maeda,Randal J. Kaufman,Lars Eckmann,Donald G. Guiney,Michael Karin +8 more
TL;DR: This work has found that the anthrax bacterium, Bacillus anthracis, selectively induces apoptosis of activated macrophages through its lethal toxin, which prevents activation of the anti-apoptotic p38 mitogen-activated protein kinase.
Journal ArticleDOI
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
Matthew B. Greenblatt,Jae-Hyuck Shim,Weiguo Zou,Despina Sitara,Michelle N. Schweitzer,Dorothy Hu,Sutada Lotinun,Yasuyo Sano,Roland Baron,Jin Mo Park,Simon Arthur,Min Xie,Michael D. Schneider,Bo Zhai,Steven P. Gygi,Roger J. Davis,Laurie H. Glimcher +16 more
TL;DR: It is reported that the p38 MAPK pathway is required for normal skeletogenesis in mice, and an in vivo function for p38beta is revealed and it is established that MAPK signaling is essential for bone formation in vivo.
Journal ArticleDOI
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
Olga Ananieva,Joanne Darragh,Claus Johansen,Julia M. Carr,Joanne McIlrath,Jin Mo Park,Andrew D. Wingate,Claire E. Monk,Rachel Toth,Susana G. Santos,Lars Iversen,J. Simon C. Arthur +11 more
TL;DR: The results establish MSK1 and MSK2 as key components of negative feedback mechanisms needed to limit Toll-like receptor–driven inflammation.