J
Jinbo Yang
Researcher at Lanzhou University
Publications - 61
Citations - 2975
Jinbo Yang is an academic researcher from Lanzhou University. The author has contributed to research in topics: Medicine & STAT3. The author has an hindex of 19, co-authored 45 publications receiving 2633 citations. Previous affiliations of Jinbo Yang include Cleveland Clinic Lerner Research Institute & Cleveland Clinic.
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Journal ArticleDOI
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB
TL;DR: U-STAT3 sustains cytokine-dependent signaling at late times through a mechanism completely distinct from that used by P-STAT2, and is likely to be important in physiological responses to gp130-linked cytokines and growth factors that activate STAT3, and in cancers that have constitutively active P- STAT3.
Journal Article
Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation.
Jinbo Yang,Moitreyee Chatterjee-Kishore,Susan M. Staugaitis,Hannah Nguyen,Karni Schlessinger,David E. Levy,George Stark Stark +6 more
TL;DR: Unphosphorylated STAT3, which activates gene expression by a novel mechanism distinct from that used by STAT3 dimers, is very likely to be an important transcription factor both in cancer and in responses to cytokines.
Journal ArticleDOI
Roles of unphosphorylated STATs in signaling.
Jinbo Yang,George R. Stark +1 more
TL;DR: The roles of U-STATs in transcription and regulation of gene expression are discussed, which are distinct from those used by phosphorylated STAT (P-STAT) dimers.
Journal ArticleDOI
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
Jinbo Yang,Jing Huang,Maupali Dasgupta,Nathan Sears,Masaru Miyagi,Benlian Wang,Mark R. Chance,Xing Chen,Yuping Du,Yuxin Wang,Lizhe An,Qin Wang,Tao Lu,Xiao-Dong Zhang,Zhenghe Wang,George R. Stark,George R. Stark +16 more
TL;DR: It is concluded that the lysine methylation of promoter-bound STAT3 leads to biologically important down-regulation of the dependent responses and that SET9, which is known to help provide an activating methylation mark to H3K4, is recruited to the newly activated SOCS3 promoter by STAT3.
Journal ArticleDOI
STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor
TL;DR: It is shown that prolonged activation of STAT3 results from association of the IL-6 receptor with the epidermal growth factor receptor, which in turn activates STAT3 in a way that is not inhibited by SOCS3, the major negative regulator suppressor of cytokine signaling 3.