J
Jing Ren Zhang
Researcher at University of Texas at Austin
Publications - 4
Citations - 1065
Jing Ren Zhang is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Antigenic variation & Borrelia burgdorferi. The author has an hindex of 3, co-authored 3 publications receiving 1024 citations.
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Antigenic Variation in Lyme Disease Borreliae by Promiscuous Recombination of VMP-like Sequence Cassettes
TL;DR: An elaborate genetic system in the Lyme disease spirochete Borrelia burgdorferi that promotes extensive antigenic variation of a surface-exposed lipoprotein, VlsE, could potentially produce millions of antigenic variants in the mammalian host.
Journal ArticleDOI
Genetic Variation of the Borrelia burgdorferi Gene vlsE Involves Cassette-Specific, Segmental Gene Conversion
Jing Ren Zhang,Steven J. Norris +1 more
TL;DR: Results provide evidence for a gene conversion mechanism in VlsE antigenic variation in Lyme disease spirochete Borrelia burgdorferipossesses 15 silent vls cassettes and a vlsE encoding a surface-exposed lipoprotein.
Journal ArticleDOI
Kinetics and In Vivo Induction of Genetic Variation of vlsE in Borrelia burgdorferi
Jing Ren Zhang,Steven J. Norris +1 more
TL;DR: Results indicate that vlsE recombination is induced by a factor(s) present in the mammalian host, independent of adaptive immune responses, and consistent with immune selection of VlsE variants.
Journal ArticleDOI
68Ga-Labeled Maleimide for Blood Pool and Lymph PET Imaging through Covalent Bonding to Serum Albumin In Vivo
Lixia Feng,Jianyang Fang,Xinying Zeng,Huanhuan Liu,Jing Ren Zhang,Lumei Huang,Zhide Guo,Rongqiang Zhuang,Xian-Zheng Zhang +8 more
TL;DR: Based on the promising properties of bonding covalently to albumin, great stability, high blood contrast with a long half-life, and well environmental tolerance, [68Ga]Ga-DM could be developed as a potential tracer for PET imaging of blood pool, bleeding, and vascular permeability alteration diseases in the clinic.