S
Steven J. Norris
Researcher at University of Texas Health Science Center at Houston
Publications - 163
Citations - 10328
Steven J. Norris is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Borrelia burgdorferi & Treponema. The author has an hindex of 55, co-authored 160 publications receiving 9489 citations. Previous affiliations of Steven J. Norris include Hatch Ltd & Baylor College of Medicine.
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Journal ArticleDOI
Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete
Claire M. Fraser,Steven J. Norris,George M. Weinstock,Owen White,Granger G. Sutton,Robert J. Dodson,Michelle L. Gwinn,Erin Hickey,Rebecca A. Clayton,Karen A. Ketchum,Erica Sodergren,John M. Hardham,Michael P. McLeod,Steven L. Salzberg,Jeremy Peterson,Hanif Khalak,Delwood Richardson,Jerrilyn K. Howell,Monjula Chidambaram,Teresa Utterback,Lisa McDonald,Patricia Artiach,Cheryl Bowman,Matthew D. Cotton,Claire Fujii,Stacey Garland,Bonnie Hatch,Kurt Horst,Kevin Roberts,Mina Sandusky,Janice Weidman,Hamilton O. Smith,J. Craig Venter +32 more
TL;DR: Comparison of the T. pallidum genome sequence with that of another pathogenic spirochete, Borrelia burgdorferi, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenicSpirochetes.
Journal ArticleDOI
Antigenic Variation in Lyme Disease Borreliae by Promiscuous Recombination of VMP-like Sequence Cassettes
TL;DR: An elaborate genetic system in the Lyme disease spirochete Borrelia burgdorferi that promotes extensive antigenic variation of a surface-exposed lipoprotein, VlsE, could potentially produce millions of antigenic variants in the mammalian host.
Journal ArticleDOI
Correlation between plasmid content and infectivity in Borrelia burgdorferi
Joye E. Purser,Steven J. Norris +1 more
TL;DR: Lp25 and lp28-1 appear to encode virulence factors important in the pathogenesis of B. burgdorferi B31.
Journal ArticleDOI
A plasmid‐encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host
Joye E. Purser,Matthew B. Lawrenz,Melissa J. Caimano,Jerrilyn K. Howell,Justin D. Radolf,Steven J. Norris +5 more
TL;DR: The results indicate that some plasmid‐encoded products fulfil physiological functions required in the enzootic cycle of pathogenic Borrelia, and are most probably required for the biosynthesis of NAD.
Journal ArticleDOI
Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes
Rekha Seshadri,Garry S. A. Myers,Hervé Tettelin,Jonathan A. Eisen,Jonathan A. Eisen,John F. Heidelberg,John F. Heidelberg,Robert J. Dodson,Tanja M. Davidsen,Robert T. DeBoy,Derrick E. Fouts,Daniel H. Haft,Jeremy D. Selengut,Qinghu Ren,Lauren M. Brinkac,Ramana Madupu,Jamie Kolonay,Scott Durkin,Sean C. Daugherty,Jyoti Shetty,Alla Shvartsbeyn,Elizabeth Gebregeorgis,Keita Geer,Getahun Tsegaye,Joel A. Malek,Bola Ayodeji,Sofiya Shatsman,Michael P. McLeod,David Šmajs,Jerrilyn K. Howell,Sangita Pal,Anita G. Amin,Pankaj Vashisth,Thomas Z. McNeill,Qin Xiang,Erica Sodergren,Ernesto Baca,George M. Weinstock,Steven J. Norris,Claire M. Fraser,Claire M. Fraser,Ian T. Paulsen,Ian T. Paulsen +42 more
TL;DR: Analysis of the T. denticola genome reveals factors mediating coaggregation, cell signaling, stress protection, and other competitive and cooperative measures, consistent with its pathogenic nature and lifestyle within the mixed-species environment of subgingival dental plaque.