J
John M. Hardham
Researcher at University of North Carolina at Chapel Hill
Publications - 23
Citations - 2396
John M. Hardham is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Treponema & Peptide sequence. The author has an hindex of 13, co-authored 21 publications receiving 2308 citations. Previous affiliations of John M. Hardham include University of Texas Health Science Center at Houston & University of Texas at Austin.
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Journal ArticleDOI
Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete
Claire M. Fraser,Steven J. Norris,George M. Weinstock,Owen White,Granger G. Sutton,Robert J. Dodson,Michelle L. Gwinn,Erin Hickey,Rebecca A. Clayton,Karen A. Ketchum,Erica Sodergren,John M. Hardham,Michael P. McLeod,Steven L. Salzberg,Jeremy Peterson,Hanif Khalak,Delwood Richardson,Jerrilyn K. Howell,Monjula Chidambaram,Teresa Utterback,Lisa McDonald,Patricia Artiach,Cheryl Bowman,Matthew D. Cotton,Claire Fujii,Stacey Garland,Bonnie Hatch,Kurt Horst,Kevin Roberts,Mina Sandusky,Janice Weidman,Hamilton O. Smith,J. Craig Venter +32 more
TL;DR: Comparison of the T. pallidum genome sequence with that of another pathogenic spirochete, Borrelia burgdorferi, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenicSpirochetes.
Journal ArticleDOI
Antigenic Variation in Lyme Disease Borreliae by Promiscuous Recombination of VMP-like Sequence Cassettes
TL;DR: An elaborate genetic system in the Lyme disease spirochete Borrelia burgdorferi that promotes extensive antigenic variation of a surface-exposed lipoprotein, VlsE, could potentially produce millions of antigenic variants in the mammalian host.
Journal ArticleDOI
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi.
Christoph Eicken,Vivek Sharma,Thomas Klabunde,Matthew B. Lawrenz,John M. Hardham,Steven J. Norris,James C. Sacchettini +6 more
TL;DR: The crystal structure of recombinant variant protein VlsE1 at 2.3-Å resolution reveals that the six variable regions form loop structures that constitute most of the membrane distal surface of VLSE, covering the predominantly α-helical, invariant regions of the protein.
Journal ArticleDOI
Human antibody responses to VlsE antigenic variation protein of Borrelia burgdorferi
Matthew B. Lawrenz,John M. Hardham,R. T. Owens,John Nowakowski,Allen C. Steere,G. P. Wormser,Steven J. Norris +6 more
TL;DR: The results indicate that VlsE may be useful in the immunodiagnosis of Lyme disease and may offer greater specificity than ELISAs using whole B. burgdorferi as the antigen.
Journal ArticleDOI
Characterization of a manganese-dependent regulatory protein, TroR, from Treponema pallidum
TL;DR: It is proposed that TroR represents a unique regulatory system for controlling gene expression in T. pallidum that exists as a dimer in both its inactive and active states as indicated by chemical crosslinking experiments.