Jingjing Qian

TL;DR: In a paternal mouse model given a high-fat diet, a subset of sperm transfer RNA–derived small RNAs (tsRNAs), mainly from 5′ transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression profiles and RNA modifications.

TL;DR: It is reported that tRNA methyltransferase Dnmt2 is required for sperm small-non-coding-RNA-mediated transmission of paternal metabolic disorders to the offspring and that DnMT2-mediated m5C contributes to the secondary structure and biological properties of sncRNAs, implicating sperm RNA modifications as an additional layer of paternal hereditary information.

TL;DR: Caffeine exposure during sensitive windows of pregnancy may induce epigenetic changes in the developing fetus or even the germ cells to cause adult-onset diseases in subsequent generations, suggesting the possibility of epigenetic regulation of these phenotypes in addition to genetic variants.

TL;DR: The TZ‐1 cargo spacecraft, automatic cell culture equipment and live cell imaging techniques are utilized to examine the effects of real microgravity on the proliferation and differentiation of mouse embryonic stem cells (mESCs).

TL;DR: It is shown unequivocally that preimplantation mouse embryos can develop in space, but the rate of blastocyst formation and blastocySt quality are compromised, and long-term extreme low-dose radiation is revealed as a hazardous factor for mammalian reproduction.