J
Jingliang Cheng
Researcher at Chiang Mai University
Publications - 170
Citations - 1374
Jingliang Cheng is an academic researcher from Chiang Mai University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 16, co-authored 44 publications receiving 845 citations. Previous affiliations of Jingliang Cheng include Baylor College of Medicine & Hunan Normal University.
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Journal ArticleDOI
Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration
Robert K. Koenekoop,Hui Wang,Jacek Majewski,Xia Wang,Irma Lopez,Huanan Ren,Yiyun Chen,Yumei Li,Gerald A. Fishman,Mohammed Genead,Jeremy Schwartzentruber,Naimesh Solanki,Elias I. Traboulsi,Jingliang Cheng,Clare V. Logan,Martin McKibbin,Bruce E. Hayward,David A. Parry,Colin A. Johnson,Mohammed Nageeb,James A. Poulter,Moin Mohamed,Hussain Jafri,Yasmin Rashid,Graham R. Taylor,Vafa Keser,Graeme Mardon,Huidan Xu,Chris F. Inglehearn,Qing Fu,Qing Fu,Carmel Toomes,Rui Chen +32 more
TL;DR: Functional assays of the proteins encoded by the mutant alleles identified in this study showed that the mutations reduce the enzymatic activity of NMNAT1 in NAD biosynthesis and affect protein folding.
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Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition
Md. Asaduzzaman Khan,Mousumi Tania,Chunli Wei,Zhiqiang Mei,Shelly Fu,Jingliang Cheng,Jianming Xu,Junjiang Fu +7 more
TL;DR: Thymoquinone was used to treat cancer cell lines to investigate its effects on EMT-regulatory proteins and cancer metastasis and it was demonstrated that TQ inhibited cancer cell growth, migration and invasion in a dose-dependent manner.
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MicroRNA-34a targets epithelial to mesenchymal transition-inducing transcription factors (EMT-TFs) and inhibits breast cancer cell migration and invasion
Saber Imani,Chunli Wei,Jingliang Cheng,Asaduzzaman Khan,Shangyi Fu,Luquan Yang,Mousumi Tania,Xianqin Zhang,Xiuli Xiao,Xianning Zhang,Junjiang Fu +10 more
TL;DR: Results showed that co-delivery of miR-34a and TQ is able to inactivate EMT signaling pathway by directly targeting TWIST1 and ZEB1 in BT-549 cell line, indicating that they might be a promising therapeutic combination against breast cancer metastasis.
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Prognostic Value of EMT-inducing Transcription Factors (EMT-TFs) in Metastatic Breast Cancer: A Systematic Review and Meta-analysis
TL;DR: The findings suggest that the overexpression of potentially TWIST1, SNAIL1 and especially SLUG play a key role in the aggregation of MBC treatment as well as in the improvement of follow-up plans in Asian MBC patients.
Journal ArticleDOI
Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein.
Chunli Wei,Jingliang Cheng,Boxv Zhou,Li Zhu,Md. Asaduzzaman Khan,Tao He,Sufang Zhou,Jian He,Xiaoling Lu,Hanchun Chen,Dianzheng Zhang,Yongxiang Zhao,Junjiang Fu +12 more
TL;DR: A novel mechanism in breast cancer cells is revealed that TRIM28 enhances metastasis by stabilizing TWIST1 and subsequently enhancing EMT, suggesting that targeting TRim28 could be an efficacious strategy in Breast cancer treatment.