Institution
Philadelphia College of Osteopathic Medicine
Education•Philadelphia, Pennsylvania, United States•
About: Philadelphia College of Osteopathic Medicine is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Randomized controlled trial & Population. The organization has 1698 authors who have published 2031 publications receiving 37679 citations. The organization is also known as: PCOM.
Topics: Randomized controlled trial, Population, Medicine, Anxiety, Cancer
Papers published on a yearly basis
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University of Calgary1, Maastricht University2, Erasmus University Rotterdam3, Royal Melbourne Hospital4, University of Amsterdam5, Bellvitge University Hospital6, Florey Institute of Neuroscience and Mental Health7, UCLA Medical Center8, University Hospital Bonn9, State University of New York System10, University of Toronto11, Beaumont Hospital12, Philadelphia College of Osteopathic Medicine13, Altair Engineering14, University of California, Los Angeles15, University of Pittsburgh16
TL;DR: Endovascular thrombectomy is of benefit to most patients with acute ischaemic stroke caused by occlusion of the proximal anterior circulation, irrespective of patient characteristics or geographical location, and will have global implications on structuring systems of care to provide timely treatment.
4,846 citations
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University of California, Los Angeles1, University of Calgary2, Erasmus University Rotterdam3, University of Melbourne4, Emory University5, Bellvitge University Hospital6, University of Tennessee at Chattanooga7, Goethe University Frankfurt8, University of Pittsburgh9, University at Buffalo10, Maastricht University11, University of Barcelona12, University Health Network13, University of Alberta14, Altair Engineering15, Philadelphia College of Osteopathic Medicine16
TL;DR: The period in which endovascular thrombectomy is associated with benefit, and the extent to which treatment delay is related to functional outcomes, mortality, and symptomatic intracranial hemorrhage are characterized are characterized.
Abstract: Importance Endovascular thrombectomy with second-generation devices is beneficial for patients with ischemic stroke due to intracranial large-vessel occlusions. Delineation of the association of treatment time with outcomes would help to guide implementation. Objective To characterize the period in which endovascular thrombectomy is associated with benefit, and the extent to which treatment delay is related to functional outcomes, mortality, and symptomatic intracranial hemorrhage. Design, Setting, and Patients Demographic, clinical, and brain imaging data as well as functional and radiologic outcomes were pooled from randomized phase 3 trials involving stent retrievers or other second-generation devices in a peer-reviewed publication (by July 1, 2016). The identified 5 trials enrolled patients at 89 international sites. Exposures Endovascular thrombectomy plus medical therapy vs medical therapy alone; time to treatment. Main Outcomes and Measures The primary outcome was degree of disability (mRS range, 0-6; lower scores indicating less disability) at 3 months, analyzed with the common odds ratio (cOR) to detect ordinal shift in the distribution of disability over the range of the mRS; secondary outcomes included functional independence at 3 months, mortality by 3 months, and symptomatic hemorrhagic transformation. Results Among all 1287 patients (endovascular thrombectomy + medical therapy [n = 634]; medical therapy alone [n = 653]) enrolled in the 5 trials (mean age, 66.5 years [SD, 13.1]; women, 47.0%), time from symptom onset to randomization was 196 minutes (IQR, 142 to 267). Among the endovascular group, symptom onset to arterial puncture was 238 minutes (IQR, 180 to 302) and symptom onset to reperfusion was 286 minutes (IQR, 215 to 363). At 90 days, the mean mRS score was 2.9 (95% CI, 2.7 to 3.1) in the endovascular group and 3.6 (95% CI, 3.5 to 3.8) in the medical therapy group. The odds of better disability outcomes at 90 days (mRS scale distribution) with the endovascular group declined with longer time from symptom onset to arterial puncture: cOR at 3 hours, 2.79 (95% CI, 1.96 to 3.98), absolute risk difference (ARD) for lower disability scores, 39.2%; cOR at 6 hours, 1.98 (95% CI, 1.30 to 3.00), ARD, 30.2%; cOR at 8 hours,1.57 (95% CI, 0.86 to 2.88), ARD, 15.7%; retaining statistical significance through 7 hours and 18 minutes. Among 390 patients who achieved substantial reperfusion with endovascular thrombectomy, each 1-hour delay to reperfusion was associated with a less favorable degree of disability (cOR, 0.84 [95% CI, 0.76 to 0.93]; ARD, −6.7%) and less functional independence (OR, 0.81 [95% CI, 0.71 to 0.92], ARD, −5.2% [95% CI, −8.3% to −2.1%]), but no change in mortality (OR, 1.12 [95% CI, 0.93 to 1.34]; ARD, 1.5% [95% CI, −0.9% to 4.2%]). Conclusions and Relevance In this individual patient data meta-analysis of patients with large-vessel ischemic stroke, earlier treatment with endovascular thrombectomy + medical therapy compared with medical therapy alone was associated with lower degrees of disability at 3 months. Benefit became nonsignificant after 7.3 hours.
1,544 citations
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TL;DR: This study provides valuable insights into how CD2AP contributes to LOAD susceptibility and results resulted in a significant increase in extracellular amyloid-B (Ab) levels, which did not appear to be directly related to changes in APP processing.
Abstract: brain. To investigate this, we are characterising the effects of CD2AP knockdown in an in vitro model of the BBB. Methods: Endogenous CD2AP expression was knocked down in H4 and hMEC/D3 cells using siRNA. Knockdown was quantified by western blot and Image J analysis. Levels of APP, Ab, and APP metabolites were quantified using ELISAs. The rate of receptor-mediated endocytosis was measured by a transferrin uptake assay. Co-localisation of CD2AP with APP and endosomal markers was assessed using immunocytochemistry. Transcytosis in hMEC/D3 cells will be assessed using Transwell assays. Results:We observed a significant 30.2760.07 % increase in Ab40 expression (p1⁄40.0046). Expression levels of APP and APP processing metabolites was not significantly altered. Results from our experiments in progress will be made available at AAIC 2016. Conclusions:Knockdown of CD2AP expression resulted in a significant increase in extracellular amyloid-B (Ab) levels, which did not appear to be directly related to changes in APP processing. This study is ongoing and novel data will be presented at AAIC 2016. Overall, our study provides valuable insights into how CD2AP contributes to LOAD susceptibility.
771 citations
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TL;DR: CPNB analgesia, regardless of catheter location, provided superior postoperative analgesia and fewer opioid-related side effects when compared with opioid analgesia.
Abstract: Although most randomized clinical trials conclude that the addition of continuous peripheral nerve blockade (CPNB) decreases postoperative pain and opioid-related side effects when compared with opioids, studies have included relatively small numbers of patients and the majority failed to show stati
635 citations
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TL;DR: The SAXS pipeline combines automated sample handling of microliter volumes, temperature and anaerobic control, rapid data collection and data analysis, and couples structural analysis with automated archiving to create an efficient pipeline enabling high-throughput analysis of protein structure in solution with small angle X-ray scattering.
Abstract: We present an efficient pipeline enabling high-throughput analysis of protein structure in solution with small angle X-ray scattering (SAXS). Our SAXS pipeline combines automated sample handling of microliter volumes, temperature and anaerobic control, rapid data collection and data analysis, and couples structural analysis with automated archiving. We subjected 50 representative proteins, mostly from Pyrococcus furiosus, to this pipeline and found that 30 were multimeric structures in solution. SAXS analysis allowed us to distinguish aggregated and unfolded proteins, define global structural parameters and oligomeric states for most samples, identify shapes and similar structures for 25 unknown structures, and determine envelopes for 41 proteins. We believe that high-throughput SAXS is an enabling technology that may change the way that structural genomics research is done.
604 citations
Authors
Showing all 1711 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stephen J. Lippard | 141 | 1201 | 89269 |
Shaun Purcell | 120 | 326 | 132973 |
Michael W. W. Adams | 83 | 473 | 24425 |
Susan R. Weiss | 63 | 246 | 12344 |
Stephen P. Cramer | 61 | 284 | 11031 |
Anny H. Xiang | 50 | 179 | 12881 |
Zachary Simmons | 47 | 180 | 7325 |
Huy Nguyen | 46 | 308 | 22290 |
Nirmal C. Tejwani | 45 | 175 | 6650 |
Richard E. White | 38 | 81 | 4145 |
Walter C. Prozialeck | 37 | 99 | 4805 |
Francis E. Jenney | 34 | 65 | 3797 |
Annette Langer-Gould | 33 | 84 | 8348 |
David M. O’Sullivan | 32 | 190 | 3339 |
Dianzheng Zhang | 30 | 84 | 3357 |