Jingwei Zhang

TL;DR: It is demonstrated that circSMARCA5 can bind to its parent gene locus, forming an R-loop, which results in transcriptional pausing at exon 15 of SMarCA5, which revealed a new regulatory mechanism for circRNA on its host gene and provided evidence that circ SMAR CA5 may serve as a therapeutic target for drug-resistant breast cancer patients.

TL;DR: The findings suggest that the inhibitory effect of EGCG on MCF-7 cell migration and invasion may be produced by a down regulation of VASP expression via the Rac1 pathway.

TL;DR: Results indicate that icariin exerts negative effects on tumor cell invasion and migration via the Rac1-dependent VASP pathway and may be a potential anti-cancer drug.

TL;DR: It is demonstrated that VASP was upregulated by epidermal growth factor (EGF) and promoted the migration and invasion of gastric cancer cells and the identification of miR-610 as a novel miRNA regulated by EGF that targets VasP in gastriccancer cells suggests that EGF-miR610-VASP axis may be exploited for therapeutic intervention to inhibit gastric cancers progression and metastasis.

TL;DR: This study demonstrated that down-regulation of METTL14 and ZC3H13 which act as two tumor suppressor genes was found in breast cancer and predicted poor prognosis.