Jingwen Liu

TL;DR: In this article, a highly conserved hepatocyte nuclear factor 1 (HNF1) binding site was identified as a critical sequence motif for PCSK9 transcription and its regulation by BBR.

TL;DR: It is demonstrated that in addition to an increase in sterol response element binding protein 2 (SREBP2) expression, rosuvastatin treatment increased the liver expression of hepatocyte nuclear factor 1 α (HNF1α), the newly identified key transactivator for PCSK9 gene expression.

TL;DR: It is demonstrated that inhibition of cell growth leads to a decreased mRNA expression and an increased DNA methylation of SNCG gene, and this strongly suggest that DNA hypomethylation is a common mechanism underlying the abnormal expression of this candidate oncogene in breast and ovarian carcinomas.

TL;DR: It is demonstrated that the BBR-induced stabilization of LDLR mRNA is mediated by the ERK signaling pathway through interactions of cis-regulatory sequences of 3′UTR and mRNA binding proteins that are downstream effectors of this signaling cascade.

TL;DR: It is shown that the neuronal protein synuclein-gamma (SNCG) is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, but rarely expressed in tumor-matched nonneoplastic adjacent tissues, suggesting that its expression in primary carcinomas is an effective molecular indicator of distant metastasis.