Jinlong He

TL;DR: This is the first study incorporating public GWAS results formally into the standard GBLUP model and it is thought that the BLUP|GA approach deserves further investigations in animal breeding, plant breeding as well as human genetics.

TL;DR: Predictive ability and difference of accuracies for BLUP|GA and GBLUP significantly correlate with the distance between the T and G matrices, which is mainly due to the increased similarity between the trait-specific relationship matrix (T matrix) and the genetic relationship matrix at unobserved causal loci.

TL;DR: The genome-wide profile of DNA methylation in porcine ovaries is investigated at single-base resolution using reduced representation bisulfite sequencing and found hypermethylation frequently occurred in regions with low gene abundance, while hypomethylation in areas with high gene abundance.

TL;DR: Knowledge of traits’ genetic architectures can be integrated into practices of genomic prediction by assigning locus-specific priors to markers, which will help Bayesian approaches perform better in variable selection and marker effects shrinkage.

TL;DR: The results showed the potential of implementing genomic selection in small breeding herds by increasing the selection accuracy by 20% or more depending on the prediction model used, the trait under consideration, and the genetic connectedness between the training and validation individuals.