Jinwei Zhang

TL;DR: A previously unrecognized contribution of CSF hypersecretion to the pathogenesis of PHH is uncovered, a new role for TLRs in regulation of the internal brain milieu is demonstrated, and a kinase-regulated mechanism of CSf secretion that could be targeted by repurposed US Food and Drug Administration (FDA)-approved drugs to treat hydrocephalus is identified.

TL;DR: The genetic and biochemical experiments that led to the discovery of the molecular components involved in this essential physiological regulatory pathway that controls intracellular Cl− concentration are described, with five figures and 115 references.

TL;DR: It is shown that the binding of ubiquitinPhospho‐Ser65 to Parkin disrupts the interaction between the Ubl domain and C‐terminal region, thereby increasing the accessibility of Parkin Ser65.

TL;DR: Understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling is furthered, and novel roles for this pathway in immune cell function and cell proliferation are uncovered.

TL;DR: The targeting of WNK–SPAK/OSR1 with kinase inhibitors might be a novel potent strategy to enhance cellular Cl− extrusion, with potential implications for the therapeutic modulation of epithelial and neuronal ion transport in human disease states.