Jiong Ma

TL;DR: This approach reveals that a single viscous central channel in the NPC acts as the sole pathway for passive diffusion of various small molecules; transport receptors and their cargo complexes take distinct transport routes in the periphery, which is occluded by phenylalanine-glycine filaments.

TL;DR: This study developed single-point edge-excitation subdiffraction microscopy to obtain a three-dimensional density map of the transient interactions with a spatiotemporal resolution of 9 nm and 400 μs and observed three unique features under real-time trafficking conditions that have escaped detection by conventional electron microscopy.

TL;DR: It is found that the water-soluble thiol-capped CdTe QDs can photoproduce 1O2 in deuterated water with a low quantum yield (QY) of 1%, which may facilitate the applications of QD-Pc composites in broad areas.

TL;DR: By comparing the photostability of QDs in C2C12 cells with and without NaN3 treatment, the photooxidation effect of 1O2 on photobleaching of cellular QDs was confirmed and the linear relationship in Stern-Volmer measurements between the terminal product and the concentration of NaN 3 demonstrated that1O2 was the main pathway of the photobelaching in QD solutions.

TL;DR: A 3D reconstruction of the export route indicates that mRNPs primarily interact with the periphery on the nucleoplasmic side and in the center of the NPC, without entering the central axial conduit utilized for passive diffusion of small molecules, and eventually dissociate on the cytoplasmicside.