J
Jiping Zeng
Researcher at University of Nebraska Medical Center
Publications - 2
Citations - 23
Jiping Zeng is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 1, co-authored 2 publications receiving 9 citations.
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Journal ArticleDOI
Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer
Heyu Song,Jiping Zeng,Shrabasti Roychoudhury,Pranjal Biswas,Bhopal Mohapatra,Sutapa Ray,Kayvon Dowlatshahi,Jing Wang,Vimla Band,Geoffrey A. Talmon,Kishor K. Bhakat +10 more
TL;DR: Targeting the FACT complex with curaxins significantly improves the 5-FU efficacy in dMMR colorectal cancer in vitro (∼50-fold decrease in IC50) and in vivo xenograft models.
Journal ArticleDOI
Histone chaperone FACT complex inhibitor CBL0137 interferes with DNA damage repair and enhances sensitivity of medulloblastoma to chemotherapy and radiation.
Heyu Song,Shaoyan Xi,Yingling Chen,Suravi Pramanik,Jiping Zeng,Shrabasti Roychoudhury,Hannah L. Harris,Anum Akbar,Salma S. Elhag,Don W. Coulter,Sutapa Ray,Kishor K. Bhakat +11 more
TL;DR: In this paper, the authors performed a comprehensive study using a cohort of 71 malignant pediatric brain tumor (MB) patients' samples and pediatric MB cell lines and found that MB tumors have elevated levels of nucleosome remodeling FACT (FAcilitates Chromatin Transcription) complex and DNA repair enzyme AP-endonuclease1 (APE1).