H
Heyu Song
Researcher at University of Nebraska Medical Center
Publications - 13
Citations - 137
Heyu Song is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 7 publications receiving 100 citations.
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Journal ArticleDOI
Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.
Shrabasti Roychoudhury,Somsubhra Nath,Heyu Song,Muralidhar L. Hegde,Larry J. Bellot,Anil K. Mantha,Shiladitya Sengupta,Sutapa Ray,Amarnath Natarajan,Kishor K. Bhakat +9 more
TL;DR: It is revealed that APE1 acetylation is an integral part of the BER pathway for maintaining genomic integrity and that AcAPE1 is exclusively present on chromatin throughout the cell cycle.
Journal ArticleDOI
Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair.
Shiladitya Sengupta,Anil K. Mantha,Anil K. Mantha,Heyu Song,Shrabasti Roychoudhury,Somsubhra Nath,Sutapa Ray,Kishor K. Bhakat +7 more
TL;DR: This study demonstrates that elevation of acetylation level of APE1 in tumor could be a novel mechanism by which cells handle the elevated levels of DNA damages in response to genotoxic stress and maintain sustained proliferation.
Journal ArticleDOI
The extracellular role of DNA damage repair protein APE1 in regulation of IL-6 expression
Somsubhra Nath,Shrabasti Roychoudhury,Matthew J. Kling,Heyu Song,Pranjal Biswas,Ashima Shukla,Hamid Band,Shantaram S. Joshi,Kishor K. Bhakat +8 more
TL;DR: It is found that monocytes secrete APE1 upon inflammatory challenges and it is shown that APE 1 is secreted through extracellular vesicles formation via endosomal sorting complex required for transport (ESCRT)-dependent pathway.
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Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer
Heyu Song,Jiping Zeng,Shrabasti Roychoudhury,Pranjal Biswas,Bhopal Mohapatra,Sutapa Ray,Kayvon Dowlatshahi,Jing Wang,Vimla Band,Geoffrey A. Talmon,Kishor K. Bhakat +10 more
TL;DR: Targeting the FACT complex with curaxins significantly improves the 5-FU efficacy in dMMR colorectal cancer in vitro (∼50-fold decrease in IC50) and in vivo xenograft models.
Journal ArticleDOI
Targeting cyclin-dependent kinase 9 sensitizes medulloblastoma cells to chemotherapy.
Heyu Song,Reeyan Bhakat,Matthew J. Kling,Don W. Coulter,Nagendra K. Chaturvedi,Sutapa Ray,Shantaram S. Joshi +6 more
TL;DR: It is shown thatCDK9 is highly expressed in MB tumors and increased CDK9 expression is correlated with high risk MB patients, and LDC067 treatment synergistically sensitizes MB cells to chemotherapeutic agent cisplatin.