Kishor K. Bhakat

TL;DR: The results suggest that KLF4 might function as an activator or repressor of transcription depending on whether it interacts with co-activators such as p300 and CREB-binding protein or co-repressors such as HDAC3.

TL;DR: It is shown that the oxidized base-specific human DNA glycosylase NEIL2 associates with RNA polymerase II and the transcriptional regulator heterogeneous nuclear ribonucleoprotein-U (hnRNP-U), both in vitro and in cells.

TL;DR: By testing a limited number of glial tumors in cell culture and also as xenografts, it is shown that mobilization of the p53 in response to TMZ damage is likely to induce a cell cycle arrest and apoptosis inglial tumors.

TL;DR: It is shown that apoptosis of mouse embryo fibroblasts triggered by APE1 inactivation can be prevented by ectopic expression of repair competent but not repair-defective APE 1, consistent with the hypothesis that aging is associated with chronic oxidative stress.

TL;DR: It is reported that p53 sequesters the Sp1 transcription factor to prevent its binding to the cognate cis elements in the MGMT promoter and thus inhibits MGMT expression, thus enhancing sensitivity of tumor cells to O(6)-alkylguanine generating drugs.