J
Jiri Eitler
Publications - 7
Citations - 281
Jiri Eitler is an academic researcher. The author has contributed to research in topics: Biology & Haematopoiesis. The author has an hindex of 2, co-authored 2 publications receiving 155 citations.
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Journal ArticleDOI
Developmental origin, functional maintenance and genetic rescue of osteoclasts
Christian E. Jacome-Galarza,Gulce Itir Percin,James E. Muller,Elvira Mass,Elvira Mass,Tomi Lazarov,Jiri Eitler,Martina Rauner,Vijay K. Yadav,Lucile Crozet,Mathieu Bohm,Pierre-Louis Loyher,Gerard Karsenty,Claudia Waskow,Frederic Geissmann +14 more
TL;DR: It is reported that osteoclasts that colonize fetal ossification centres originate from embryonic erythro-myeloid progenitors and are maintained after birth by fusion with circulating monocytes, and parabiosis or transfusion of monocytic cells results in long-term gene transfer in osteoclast in the absence of haematopoietic-stem-cell chimerism.
Journal ArticleDOI
CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages.
Gulce Itir Percin,Jiri Eitler,Andrea Kranz,Jun Fu,Jeffrey W. Pollard,Ronald Naumann,Claudia Waskow +6 more
TL;DR: It is shown that combining FLT3 and CSF1R-deficiencies results in specific and complete abrogation of spleen DCs in vivo, providing a novel regulatory principle that may also be important for the differentiation of other hematopoietic cell types.
Journal ArticleDOI
Immunotherapy: DUAL TARGETING OF CAR-NK CELLS TO PD-L1 AND HER2 FACILITATES SPECIFIC ELIMINATION OF CANCER CELLS OF SOLID TUMOR ORIGIN AND OVERCOMES IMMUNE ESCAPE BY ANTIGEN LOSS
Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer
Paola Ortiz Montero,Anastasia Kurzyukova,Wiebke Rackwitz,Stephan R Künzel,Winfried S. Wels,Torsten Tonn,Franziska Knopf,Jiri Eitler +7 more
TL;DR: In this paper , a zebrafish larval xenograft model was used to test the efficacy of CAR-NK cells against metastatic breast cancer in vivo by injecting metastatic cancer cells into the Duct of Cuvier (DoC).
Book ChapterDOI
Live-cell imaging for analysis of the NK cell immunological synapse
TL;DR: In this article , live-cell imaging was used to analyze the processes at the immunological synapse (IS) between NK cells and cancer cells, with a focus on mechanisms of cancer cell resistance facilitating escape from NK cell cytotoxicity.