Tomi Lazarov

TL;DR: It is reported that osteoclasts that colonize fetal ossification centres originate from embryonic erythro-myeloid progenitors and are maintained after birth by fusion with circulating monocytes, and parabiosis or transfusion of monocytic cells results in long-term gene transfer in osteoclast in the absence of haematopoietic-stem-cell chimerism.

TL;DR: These experiments of nature show that human IL-12 and IL-23 are both required for optimal IFN-γ–dependent immunity to mycobacteria, both individually and much more so cooperatively.

TL;DR: Homozygosity for the catalytically inactive P1104A missense variant of the TYK2 Janus kinase selectively disrupts the induction of IFN-γ by IL-23 and is a common monogenic etiology of tuberculosis.

TL;DR: It is shown that mosaic expression of BRAF(V600E) in mouse EMPs results in clonal expansion of tissue-resident macrophages and a severe late-onset neurodegenerative disorder, which is associated with accumulation of ERK-activated amoeboid microglia in mice and is also observed in human patients with histiocytoses.

TL;DR: Autosomal recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine growth retardation, chronic neutropenia, and NK cell deficiency.