Jiye Aa

TL;DR: It is demonstrated that CD147 is a critical regulator of fatty acid metabolism, which provides a strong line of evidence for this molecule to be used as a drug target in cancer treatment.

TL;DR: Because incubation affected the analyte peak areas less in serum than in plasma, the results highlight the importance in choosing serum or plasma as the analytical sample and in stipulating the incubation time.

TL;DR: BBR prevented the development of high-fat-diet–induced obesity and ameliorated triglyceride accumulation in livers of WT, but not FXRint−/− mice, and results indicate that BBR may exert its lipid-lowering effect primarily in the gut by modulating the turnover of bile acids and subsequently the ileal FXR signaling pathway.

TL;DR: Findings indicate that the Nrf2/FXR/LXRα pathway might synergistically regulate both endogenous and exogenous metabolism in NAFLD mice and LXRα may be a novel therapeutic target of curcumin for the prevention and treatment of NAFLd.

TL;DR: To probe potential markers and the underlying mechanism ofDN, an animal model of DN, the db/db mice, was used and serum and urine metabolites were profiled using gas chromatography/time-of-flight mass spectrometry to suggest perturbations in the tricarboxylic acid cycle, lipid metabolism, glycolysis, and amino acid turnover.