J
Jiyoung Park
Researcher at Ulsan National Institute of Science and Technology
Publications - 186
Citations - 6049
Jiyoung Park is an academic researcher from Ulsan National Institute of Science and Technology. The author has contributed to research in topics: Medicine & Adipose tissue. The author has an hindex of 38, co-authored 139 publications receiving 5059 citations. Previous affiliations of Jiyoung Park include Seoul National University & University of Texas Southwestern Medical Center.
Papers
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Obesity and cancer—mechanisms underlying tumour progression and recurrence
TL;DR: Recent advances in understanding the contributions of obesity to cancer and their implications for tumour treatment are discussed.
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MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.
Christine M. Kusminski,William L. Holland,Kai Sun,Jiyoung Park,Stephen B. Spurgin,Ying Lin,G Roger Askew,Judith Simcox,Donald A. McClain,Cai Li,Philipp E. Scherer +10 more
TL;DR: It is found that overexpression of mitoNEET enhances lipid uptake and storage, leading to an expansion of the mass of adipose tissue, causing less weight gain on a high-fat diet.
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Paracrine and endocrine effects of adipose tissue on cancer development and progression
TL;DR: The role of adipocyte dysfunction associated with obesity and its potential impact on cancer biology is discussed.
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Adipocyte-derived endotrophin promotes malignant tumor progression.
Jiyoung Park,Philipp E. Scherer +1 more
TL;DR: A cleavage product of the COL6α3 chain, endotrophin (ETP), is described, which serves as the major mediator of theCOL6-mediated tumor effects and highlights the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells.
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Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction
Kai Sun,Jiyoung Park,Olga T. Gupta,William L. Holland,Pernille Auerbach,Ningyan Zhang,Roberta Goncalves Marangoni,Sarah M. Nicoloro,Michael P. Czech,John Varga,Thorkil Ploug,Zhiqiang An,Philipp E. Scherer +12 more
TL;DR: It is demonstrated that endotrophin plays a pivotal role in shaping a metabolically unfavourable microenvironment in adipose tissue during consumption of a high-fat diet (HFD) and is established as a potential target in the context of metabolism and cancer.