Ningyan Zhang

TL;DR: TREM2 is demonstrated as a microglial Aβ receptor transducing physiological and AD-related pathological effects associated with Aβ, and TREM2 interaction with its signaling adaptor DAP12 is enhanced by A β, regulating downstream phosphorylation of SYK and GSK3β.

TL;DR: It is demonstrated that endotrophin plays a pivotal role in shaping a metabolically unfavourable microenvironment in adipose tissue during consumption of a high-fat diet (HFD) and is established as a potential target in the context of metabolism and cancer.

TL;DR: In vitro activities of inhibitory Notch1 monoclonal antibodies derived from cell-based and solid-phase screening of a phage display library may have clinical utility for conditions in which inhibition of signaling by wild-type notch1 is desired, but are likely to be of limited value for treatment of T-ALLs associated with aberrant Notch 1 activation.

TL;DR: Direct evolution is used to create CALB mutants with improved resistance towards irreversible thermal inactivation and over a 20-fold increase in half-life at 70 degrees C compared with the wild-type CALB (WT-CALB).

TL;DR: Results indicated that activation of macrophages in combination with trastuzumab can serve as a therapeutic strategy for treating high HER2 breast cancer by boosting ADCP killing of cancer cells.