Sarthak Sinha

TL;DR: Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and disease by producing complex extracellular matrix and creating signaling niches through biophysical and biochemical cues.

TL;DR: It is demonstrated that after injury, including in humans, macrophages function to clear debris and persist within the nerve microenvironment and highlight a molecular mechanism by which this occurs.

TL;DR: The restriction of peripheral inflammation by microglia may be a previously unidentified mechanism by which the central nervous system maintains its “immune privileged” status.

TL;DR: It is shown that hair follicle mesenchymal progenitors make limited contributions to wound repair, and pharmacological modulation of RUNX1 and retinoic acid signaling or genetic deletion of Hic1 within wound-activated fibroblasts was sufficient to modulate healing outcomes, suggesting that reparative fibro Blasts have latent but modifiable regenerative capacity.

TL;DR: Five distinct approaches to minimize donor site pain are revealed and recommended treatments include: subcutaneous anesthetic injection of adrenaline-lidocaine, ice application, topical agents, such as lidocaine and bupivacaine, and wound dressings accompanied with fibrin sealant.