J
Joachim Frank
Researcher at Columbia University
Publications - 482
Citations - 42195
Joachim Frank is an academic researcher from Columbia University. The author has contributed to research in topics: Ribosome & Eukaryotic Ribosome. The author has an hindex of 103, co-authored 473 publications receiving 39475 citations. Previous affiliations of Joachim Frank include Vanderbilt University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Spider and web : processing and visualization of images in 3d electron microscopy and related fields
Joachim Frank,Michael Radermacher,Michael Radermacher,Pawel A. Penczek,Jun Zhu,Jun Zhu,Yanhong Li,Mahieddine Ladjadj,Ardean Leith +8 more
TL;DR: Novel features are a suite of operations relating to the determination, modeling, and correction of the contrast transfer function and the availability of the entire documentation in hypertext format.
MonographDOI
Three-Dimensional Electron Microscopy of Macromolecular Assemblies
TL;DR: In this article, a three-dimensional reconstruction interpretation of 3D images of macromolecules is presented. Butts et al. reconstructed macromoles from micrographs of single macromolcules.
Journal ArticleDOI
Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics
TL;DR: A novel method to flexibly fit atomic structures into electron microscopy (EM) maps using molecular dynamics simulations is presented, incorporating the EM data as an external potential added to the molecular dynamics force field.
Journal ArticleDOI
A ratchet-like inter-subunit reorganization of the ribosome during translocation.
TL;DR: Three-dimensional cryo-electron microscopy maps of the Escherichia coli 70S ribosome in various functional states show that both EF-G binding and subsequent GTP hydrolysis lead to ratchet-like rotations of the small 30S sub unit relative to the large 50S subunit, indicating a two-step mechanism of translocation.
Journal ArticleDOI
Locking and unlocking of ribosomal motions.
Mikel Valle,A. Zavialov,Jayati Sengupta,U. Rawat,U. Rawat,Måns Ehrenberg,Joachim Frank,Joachim Frank,Joachim Frank +8 more
TL;DR: During the ribosomal translocation, the binding of elongation factor G to the pretranslocational ribosome leads to a ratchet-like rotation of the 30S sub unit relative to the 50S subunit in the direction of the mRNA movement, implying that this region is involved in the translocation of deacylated tRNAs from the P to the E site.