J
Joan G. Jones
Researcher at Albert Einstein College of Medicine
Publications - 80
Citations - 6047
Joan G. Jones is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Metastasis & Breast cancer. The author has an hindex of 36, co-authored 78 publications receiving 5307 citations. Previous affiliations of Joan G. Jones include Yeshiva University & Cornell University.
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Journal ArticleDOI
Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases
Elaine Y. Lin,Joan G. Jones,Ping Li,Liyin Zhu,Kathleen Whitney,William J. Muller,Jeffrey W. Pollard +6 more
TL;DR: The PyMT mouse model is demonstrated to be an excellent one to understand the biology of tumor progression in humans, and its comparison to human breast tumors is compared.
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Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA
Allison S. Harney,Esther N. Arwert,David Entenberg,Yarong Wang,Peng Guo,Bin-Zhi Qian,Maja H. Oktay,Jeffrey W. Pollard,Jeffrey W. Pollard,Joan G. Jones,John S. Condeelis +10 more
TL;DR: Show that VEGFA signaling from TIE2(hi) TMEM macrophages results in local, transient vascular permeability and tumor cell intravasation, providing evidence for the mechanism underlying the association of TMEM with distant metastatic recurrence, offering a rationale for therapies targeting TMEM.
Journal Article
A Critical Step in Metastasis: In Vivo Analysis of Intravasation at the Primary Tumor
TL;DR: It is demonstrated that a major difference in intravasation between metastatic and nonmetastatic cells is detected in the primary tumor and the value of a direct visualization of cell properties in vivo for dissection of the metastatic process is illustrated.
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Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism
George S. Karagiannis,Jessica Pastoriza,Yarong Wang,Allison S. Harney,David Entenberg,Jeanine Pignatelli,Ved P. Sharma,Emily A. Xue,Esther Cheng,Timothy M. D'Alfonso,Joan G. Jones,Jesus Anampa,Thomas E. Rohan,Joseph A. Sparano,John S. Condeelis,Maja H. Oktay,Maja H. Oktay +16 more
TL;DR: Results indicate that TMEM score increases and MENA isoform expression pattern changes with chemotherapy and can be used in predicting prometastatic changes in response to chemotherapy.
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Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination
Brian D. Robinson,Gabriel Sica,Yi Fang Liu,Thomas E. Rohan,Frank B. Gertler,John S. Condeelis,Joan G. Jones +6 more
TL;DR: In this paper, the authors defined TMEM as the tripartite arrangement of an invasive carcinoma cell, a macrophage, and an endothelial cell, and found that TMEM density predicted the development of systemic, hematogenous metastases.