Jesus Anampa

TL;DR: Results indicate that TMEM score increases and MENA isoform expression pattern changes with chemotherapy and can be used in predicting prometastatic changes in response to chemotherapy.

TL;DR: Although adjuvant treatments are routinely guided by predictive factors for endocrine therapy (hormone receptor expression) and anti-HER2 therapy (HER2 overexpression), predicting benefit from chemotherapy has been more challenging.

TL;DR: Dual inhibition of MDMX and MDM2 by an α-helical p53-stapled peptide (ALRN-6924) results in robust antitumor activity in acute myeloid leukemia and provides mechanistic insight to support further testing of ALRN- 6924 as a therapeutic approach in AML and other cancers with wild-type p53.

TL;DR: In this article, the anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial, and the authors detected the waning of immunity 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing and 56% of seronegative patients seroconverted post-booster vaccination.

TL;DR: It is suggested that anthracyclines should not be spared for patients with triple negative breast cancer (regardless of axillary node involvement) or HER2−/ER+ with significant node involvement, and further research is required to delineate their proper utility in the clinical setting.