M
Maja H. Oktay
Researcher at Albert Einstein College of Medicine
Publications - 104
Citations - 4173
Maja H. Oktay is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Metastasis & Breast cancer. The author has an hindex of 26, co-authored 78 publications receiving 3136 citations. Previous affiliations of Maja H. Oktay include Memorial Sloan Kettering Cancer Center & Yale University.
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Journal ArticleDOI
Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA
Allison S. Harney,Esther N. Arwert,David Entenberg,Yarong Wang,Peng Guo,Bin-Zhi Qian,Maja H. Oktay,Jeffrey W. Pollard,Jeffrey W. Pollard,Joan G. Jones,John S. Condeelis +10 more
TL;DR: Show that VEGFA signaling from TIE2(hi) TMEM macrophages results in local, transient vascular permeability and tumor cell intravasation, providing evidence for the mechanism underlying the association of TMEM with distant metastatic recurrence, offering a rationale for therapies targeting TMEM.
Journal ArticleDOI
An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype
Irina M. Shapiro,Albert W. Cheng,Nicholas C. Flytzanis,Michele Balsamo,John S. Condeelis,Maja H. Oktay,Christopher B. Burge,Frank B. Gertler +7 more
TL;DR: In this paper, an alternative splicing signature for EMT was determined using an established cell culture model and RNA-Seq analyses, which indicated that most EMT-associated alternatively splicing events are regulated by one or more members of the RBFOX, MBNL, CELF, hnRNP, or ESRP classes of splicing factors.
An EMT-Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype
Irina M. Shapiro,Albert W. Cheng,Nicholas C. Flytzanis,Michele Balsamo,John S. Condeelis,Maja H. Oktay,Christopher B. Burge,Frank B. Gertler +7 more
TL;DR: The analysis suggested that most EMT–associated alternative splicing events are regulated by one or more members of the RBFOX, MBNL, CELF, hnRNP, or ESRP classes of splicing factors.
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Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism
George S. Karagiannis,Jessica Pastoriza,Yarong Wang,Allison S. Harney,David Entenberg,Jeanine Pignatelli,Ved P. Sharma,Emily A. Xue,Esther Cheng,Timothy M. D'Alfonso,Joan G. Jones,Jesus Anampa,Thomas E. Rohan,Joseph A. Sparano,John S. Condeelis,Maja H. Oktay,Maja H. Oktay +16 more
TL;DR: Results indicate that TMEM score increases and MENA isoform expression pattern changes with chemotherapy and can be used in predicting prometastatic changes in response to chemotherapy.
Journal ArticleDOI
Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle
Maja H. Oktay,Maja H. Oktay,Kishore K. Wary,Michael Dans,Raymond B. Birge,Filippo G. Giancotti +5 more
TL;DR: Findings establish a role for FAK in both the activation of JNK and the control of the cell cycle, and identify a physiological stimulus for JNK signaling that is consistent with the role of Jun in both proliferation and transformation.