J
Joan Sloan
Researcher at Monash University, Clayton campus
Publications - 23
Citations - 1520
Joan Sloan is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: Dihydroxyacetone & Glycerol. The author has an hindex of 18, co-authored 23 publications receiving 1455 citations. Previous affiliations of Joan Sloan include Monash University & University of Melbourne.
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Journal ArticleDOI
The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65
Hayley J. Newton,Jaclyn S. Pearson,Luminita Badea,Michelle Kelly,Mark Lucas,Gavan Holloway,Kylie M. Wagstaff,Michelle A. Dunstone,Joan Sloan,James C. Whisstock,James B. Kaper,Roy M. Robins-Browne,David A. Jans,Gad Frankel,Alan D. Phillips,Barbara S. Coulson,Elizabeth L. Hartland +16 more
TL;DR: Overall the data show that EPEC and Shigella have evolved similar T3SS-dependent means to manipulate host inflammatory pathways by interfering with the activation of selected host transcriptional regulators.
Journal ArticleDOI
Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens
Michael Lyristis,Amy E. Bryant,Joan Sloan,Milena M. Awad,IT Nisbet,Dennis L. Stevens,Julian I. Rood +6 more
TL;DR: Virulence studies carried out using a mouse model implicated the virS gene in the pathogenesis of histotoxic C. perfringens infections and concluded that a two‐component sensor regulator system that activated the expression of a number of extracellular toxins and enzymes involved In virulence had been cloned and sequenced.
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Identification of a novel fimbrial gene cluster related to long polar fimbriae in locus of enterocyte effacement-negative strains of enterohemorrhagic Escherichia coli.
Stephen Doughty,Joan Sloan,Vicki Bennett-Wood,Vicki Bennett-Wood,Marcus Robertson,Roy M. Robins-Browne,Roy M. Robins-Browne,Elizabeth L. Hartland +7 more
TL;DR: Deletion of the putative major fimbrial subunit gene, lpfA, from EHEC O113:H21 resulted in decreased adherence of this strain to epithelial cells, suggesting that l pfO113 may function as an adhesin in LEE-negative isolates of EH EC.
Journal ArticleDOI
Shiga toxin-producing Escherichia coli strains negative for locus of enterocyte effacement.
Hayley J. Newton,Joan Sloan,Dieter M. Bulach,Torsten Seemann,Cody C. Allison,Marija Tauschek,Roy M. Robins-Browne,James C. Paton,Thomas S. Whittam,Adrienne W. Paton,Elizabeth L. Hartland +10 more
TL;DR: The ehx plasmids of these strains are highly related, which suggests acquisition of the large plasmid was central to the strains’ emergence.
Journal ArticleDOI
Construction of a sequenced Clostridium perfringens-Escherichia coli shuttle plasmid.
TL;DR: A new Clostridium perfringens-Escherichia coli shuttle plasmid has been constructed and its complete DNA sequence compiled, which means that X-gal screening can be used to select recombinants in E. coli.