M
Michelle Kelly
Researcher at Curtin University
Publications - 111
Citations - 2615
Michelle Kelly is an academic researcher from Curtin University. The author has contributed to research in topics: Medicine & Health care. The author has an hindex of 24, co-authored 94 publications receiving 2082 citations. Previous affiliations of Michelle Kelly include Boston Children's Hospital & University of Melbourne.
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Journal ArticleDOI
A type III effector antagonizes death receptor signalling during bacterial gut infection
Jaclyn S. Pearson,Cristina Giogha,Sze Ying Ong,Catherine Kennedy,Michelle Kelly,Keith S. Robinson,Tania Wong Fok Lung,Ashley Mansell,Patrice Riedmaier,Claire Vl Oates,Ali Zaid,Sabrina Mühlen,Valerie F. Crepin,Oliver Marchès,Ching-Seng Ang,Nicholas A. Williamson,Lorraine A. O'Reilly,Lorraine A. O'Reilly,Aleksandra Bankovacki,Ueli Nachbur,Giuseppe Infusini,Andrew I. Webb,Andrew I. Webb,John Silke,John Silke,Andreas Strasser,Andreas Strasser,Gad Frankel,Elizabeth L. Hartland,Elizabeth L. Hartland +29 more
TL;DR: The activity of NleB suggests that EPEC and other attaching and effacing pathogens antagonize death-receptor-induced apoptosis of infected cells, thereby blocking a major antimicrobial host response.
Journal ArticleDOI
The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65
Hayley J. Newton,Jaclyn S. Pearson,Luminita Badea,Michelle Kelly,Mark Lucas,Gavan Holloway,Kylie M. Wagstaff,Michelle A. Dunstone,Joan Sloan,James C. Whisstock,James B. Kaper,Roy M. Robins-Browne,David A. Jans,Gad Frankel,Alan D. Phillips,Barbara S. Coulson,Elizabeth L. Hartland +16 more
TL;DR: Overall the data show that EPEC and Shigella have evolved similar T3SS-dependent means to manipulate host inflammatory pathways by interfering with the activation of selected host transcriptional regulators.
Journal ArticleDOI
Discovery of an archetypal protein transport system in bacterial outer membranes
Joel Selkrig,Khedidja Mosbahi,Chaille T. Webb,Matthew J. Belousoff,Andrew J. Perry,Timothy J. Wells,Faye C. Morris,Denisse L. Leyton,Denisse L. Leyton,Makrina Totsika,Minh-Duy Phan,Nermin Celik,Michelle Kelly,Clare V. Oates,Elizabeth L. Hartland,Roy M. Robins-Browne,Roy M. Robins-Browne,Sri H. Ramarathinam,Anthony W. Purcell,Mark A. Schembri,Richard A. Strugnell,Ian R. Henderson,Daniel Walker,Trevor Lithgow +23 more
TL;DR: The translocation and assembly module (TAM) as mentioned in this paper has been found to promote the efficient secretion of autotransporters in proteobacteria and is a new target for the development of therapies to inhibit colonization by bacterial pathogens.
Journal ArticleDOI
Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium.
Michelle Kelly,Emily Hart,Rosanna Mundy,Olivier Marchès,Siouxsie Wiles,Luminita Badea,Shelley Narelle Luck,Marija Tauschek,Gad Frankel,Roy M. Robins-Browne,Elizabeth L. Hartland,Elizabeth L. Hartland +11 more
TL;DR: In this article, a signature-tagged mutagenesis screen was performed in C57BL/6 mice by using the mouse A/E pathogen Citrobacter rodentium.
Journal ArticleDOI
Use of simulated patients to develop communication skills in nursing education: An integrative review
TL;DR: The evidence indicated indicates that the use of SPs to teach nurse-patient communication skills targets more challenging clinical interactions and expanding the utilisation ofSPs to augment nurses' communication skills and ability to engage with patients in a broader range of clinical contexts with increased methodological rigor is recommended.