M
Michelle A. Dunstone
Researcher at Monash University
Publications - 53
Citations - 4018
Michelle A. Dunstone is an academic researcher from Monash University. The author has contributed to research in topics: MACPF & Perforin. The author has an hindex of 32, co-authored 52 publications receiving 3520 citations. Previous affiliations of Michelle A. Dunstone include Monash University, Clayton campus & St. Vincent's Institute of Medical Research.
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Journal ArticleDOI
The structural basis for membrane binding and pore formation by lymphocyte perforin
Ruby H. P. Law,Natalya Lukoyanova,Ilia Voskoboinik,Ilia Voskoboinik,Tom T. Caradoc-Davies,Katherine Baran,Michelle A. Dunstone,Michelle A. Dunstone,Michael E. D'Angelo,Elena V. Orlova,Fasséli Coulibaly,Sandra Verschoor,Kylie A. Browne,Annette Ciccone,Michael J. Kuiper,Phillip I. Bird,Joseph A. Trapani,Joseph A. Trapani,Helen R. Saibil,James C. Whisstock,James C. Whisstock +20 more
TL;DR: In this article, the X-ray crystal structure of perforin pore formation was determined using a cryo-electron microscopy reconstruction, which revealed remarkable flexibility in the mechanism of action and provided new insights into how related immune defence molecules such as complement proteins assemble into pores.
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A Common Fold Mediates Vertebrate Defense and Bacterial Attack
Carlos J. Rosado,Ashley M. Buckle,Ruby H. P. Law,Rebecca Elizabeth Butcher,Rebecca Elizabeth Butcher,Wan-Ting Kan,Wan-Ting Kan,Catherina H. Bird,Kheng Sok Ung,Kylie A. Browne,Katherine Baran,Tanya Ann Bashtannyk-Puhalovich,Noel G. Faux,Wilson Wong,Wilson Wong,Corrine Joy Porter,Corrine Joy Porter,Robert N. Pike,Andrew M. Ellisdon,Mary Catherine Pearce,Stephen P. Bottomley,Jonas Emsley,A. Ian Smith,A. Ian Smith,Jamie Rossjohn,Jamie Rossjohn,Elizabeth L. Hartland,Ilia Voskoboinik,Ilia Voskoboinik,Joseph A. Trapani,Joseph A. Trapani,Phillip I. Bird,Michelle A. Dunstone,James C. Whisstock,James C. Whisstock +34 more
TL;DR: Sequence similarity between bacterial and vertebrate MACPF domains suggests that the fold of the CDCs, a family of proteins important for bacterial pathogenesis, is probably used by vertebrates for defense against infection.
Journal ArticleDOI
The MACPF/CDC family of pore-forming toxins.
Carlos J. Rosado,S.C. Kondos,Tara E. Bull,Michael J. Kuiper,Ruby H. P. Law,Ashley M. Buckle,Ilia Voskoboinik,Phillip I. Bird,Joseph A. Trapani,Joseph A. Trapani,James C. Whisstock,Michelle A. Dunstone +11 more
TL;DR: Structural data suggest that lytic MACPF proteins use a CDC‐like mechanism of membrane disruption, and will help understand the roles these proteins play in immunity and development.
Journal ArticleDOI
The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65
Hayley J. Newton,Jaclyn S. Pearson,Luminita Badea,Michelle Kelly,Mark Lucas,Gavan Holloway,Kylie M. Wagstaff,Michelle A. Dunstone,Joan Sloan,James C. Whisstock,James B. Kaper,Roy M. Robins-Browne,David A. Jans,Gad Frankel,Alan D. Phillips,Barbara S. Coulson,Elizabeth L. Hartland +16 more
TL;DR: Overall the data show that EPEC and Shigella have evolved similar T3SS-dependent means to manipulate host inflammatory pathways by interfering with the activation of selected host transcriptional regulators.
Journal ArticleDOI
Perforin: structure, function, and role in human immunopathology
Ilia Voskoboinik,Michelle A. Dunstone,Katherine Baran,James C. Whisstock,Joseph A. Trapani,Joseph A. Trapani +5 more
TL;DR: This review discusses the current state of affairs in the perforin field: the protein’s structure and function as well as its role in immune‐mediated diseases.