M
Milena M. Awad
Researcher at Monash University, Clayton campus
Publications - 48
Citations - 2479
Milena M. Awad is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: Clostridium perfringens & Virulence. The author has an hindex of 21, co-authored 45 publications receiving 2150 citations. Previous affiliations of Milena M. Awad include Australian Research Council & Monash University.
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Journal ArticleDOI
Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens
Garry S. A. Myers,David A. Rasko,David A. Rasko,Jackie K. Cheung,Jacques Ravel,Rekha Seshadri,Robert T. DeBoy,Qinghu Ren,John J. Varga,Milena M. Awad,Lauren M. Brinkac,Sean C. Daugherty,Daniel H. Haft,Robert J. Dodson,Ramana Madupu,William C. Nelson,M. J. Rosovitz,Steven A. Sullivan,Hoda Khouri,George Dimitrov,Kisha Watkins,Stephanie Mulligan,Jonathan L. Benton,Diana Radune,Derek J. Fisher,Helen S. Atkins,Thomas J. Hiscox,B. Helen Jost,Stephen J. Billington,J. Glenn Songer,Bruce A. McClane,Richard W. Titball,Julian I. Rood,Stephen B. Melville,Ian T. Paulsen +34 more
TL;DR: Significant differences between the strains include numerous novel mobile elements and genes encoding metabolic capabilities, strain-specific extracellular polysaccharide capsule, sporulation factors, toxins, and other secreted enzymes, providing substantial insight into this medically important bacterial pathogen.
Journal ArticleDOI
Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease
Francisco A. Uzal,John C. Freedman,Archana Shrestha,James R. Theoret,Jorge P. Garcia,Milena M. Awad,Victoria Michelle Adams,Victoria Michelle Adams,Robert J. Moore,Robert J. Moore,Robert J. Moore,Julian I. Rood,Julian I. Rood,Bruce A. McClane,Bruce A. McClane +14 more
TL;DR: It is established that C. perfringens uses chromosomally encoded alpha toxin and perfringolysin O (a pore-forming toxin) during histotoxic infections and this bacterium causes intestinal disease by employing toxins encoded by mobile genetic elements.
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Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens.
Anthony L. Keyburn,Scott A Sheedy,Scott A Sheedy,Mark E Ford,Mark M Williamson,Milena M. Awad,Julian I. Rood,Robert J. Moore,Robert J. Moore +8 more
TL;DR: It is demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.
Journal ArticleDOI
Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens
Michael Lyristis,Amy E. Bryant,Joan Sloan,Milena M. Awad,IT Nisbet,Dennis L. Stevens,Julian I. Rood +6 more
TL;DR: Virulence studies carried out using a mouse model implicated the virS gene in the pathogenesis of histotoxic C. perfringens infections and concluded that a two‐component sensor regulator system that activated the expression of a number of extracellular toxins and enzymes involved In virulence had been cloned and sequenced.
Journal ArticleDOI
Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene.
TL;DR: The hypothesis that alpha-toxin and perfringolysin O have a synergistic effect in the pathology of gas gangrene is supported.