Joanna Zhang

TL;DR: An end-to-end differentiable recurrent geometric network that uses a protein language model (AminoBERT) to learn latent structural information from unaligned proteins and outperforms AlphaFold2 and RoseTTAFold on orphan proteins and classes of designed proteins while achieving up to a 106-fold reduction in compute time.

TL;DR: In this article , a genetically encoded microbial encapsulation system with tunable and dynamic expression of surface capsular polysaccharides was developed to enhance systemic delivery of living bacteria therapies for treating a broad array of cancers.

TL;DR: A bacteria-in-spheroid coculture platform that enables parallel and long-term monitoring of engineered bacteria in multicellular spheroids and demonstrates high similarity between in vitro and in vivo results and shows broad applicability of the system with various bacterial species and cell types is developed.

TL;DR: A bacteria-in-spheroid co-culture (BSCC) platform that simultaneously tests host species, therapeutic payloads and synthetic gene circuits of engineered bacteria within multicellular spheroids over a timescale of weeks to accelerate synthetic biology for clinical applications and understanding the host-microbe interactions in disease sites is presented.