J
Joanne Lauber
Researcher at Washington University in St. Louis
Publications - 5
Citations - 955
Joanne Lauber is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Myelin basic protein & Antibody. The author has an hindex of 4, co-authored 5 publications receiving 901 citations.
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Journal ArticleDOI
Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients.
TL;DR: Effects of B cell depletion by rituximab, a monoclonal antibody to CD20, were studied in patients with relapsing MS that had not responded optimally to standard immunomodulatory therapies.
Journal ArticleDOI
Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells.
TL;DR: The data suggest that MBP-reactive T cells are more likely to have been activated in vivo and/or differentiated into memory T cells in MS patients compared with controls, indicating that these cells may be participating in the pathogenesis of MS.
Journal ArticleDOI
Rituximab add-on therapy for breakthrough relapsing multiple sclerosis: a 52-week phase II trial.
Robert T. Naismith,Laura Piccio,Jeri-Anne Lyons,Joanne Lauber,Nhial T. Tutlam,Becky J. Parks,Kathryn Trinkaus,Sheng-Kwei Song,Anne H. Cross +8 more
TL;DR: Rituximab add-on therapy was effective based upon blinded radiologic endpoints in this phase II study and b-cell–modulating therapy remains a potential option for treatment of patients with relapsing MS with an inadequate response to standard injectable therapies.
Journal ArticleDOI
Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients
TL;DR: The data suggest that MBP-reactive T cells are more likely to have been activated in vivo and/or differentiated into memory T cells in MS patients compared with controls, indicating that these cells may be participating in the pathogenesis of MS.
Journal ArticleDOI
Increased frequency of recognition of delipidated versus intact CNS myelin in multiple sclerosis and control subjects.
TL;DR: The results suggest that the presentation of delipidated forms of membrane proteins might enhance the response to myelin antigens in vivo, and be relevant to demyelinating diseases.