Z
Zoltan Arany
Researcher at University of Pennsylvania
Publications - 155
Citations - 15370
Zoltan Arany is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 48, co-authored 110 publications receiving 12878 citations. Previous affiliations of Zoltan Arany include Cardiovascular Institute of the South & Harvard University.
Papers
More filters
Journal ArticleDOI
Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit
TL;DR: Results suggest that an intact redox-dependent signaling pathway is required for destablization of the HIF-1α protein, which was rapidly and drastically decreased in vivo following an abrupt increase to normal oxygen tension.
Journal ArticleDOI
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Zoltan Arany,Shi-Yin Foo,Yanhong Ma,Jorge L. Ruas,Archana Bommi-Reddy,Geoffrey D. Girnun,Marcus P. Cooper,Dina Laznik,Jessica Chinsomboon,Shamina M. Rangwala,Kwan-Hyuck Baek,Anthony Rosenzweig,Bruce M. Spiegelman +12 more
TL;DR: PGC-1α and ERR-α, major regulators of mitochondrial function in response to exercise and other stimuli, also control a novel angiogenic pathway that delivers needed oxygen and substrates, and may provide a novel therapeutic target for treating ischaemic diseases.
Journal ArticleDOI
PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
Marco Sandri,Jiandie D. Lin,Christoph Handschin,Wenli Yang,Zoltan Arany,Stewart H. Lecker,Alfred L. Goldberg,Bruce M. Spiegelman +7 more
TL;DR: The high levels of P GC-1α in dark and exercising muscles can explain their resistance to atrophy, and the rapid fall in PGC-1 α during atrophy should enhance the FoxO-dependent loss of muscle mass.
Journal ArticleDOI
An essential role for p300/CBP in the cellular response to hypoxia
Zoltan Arany,L. Eric Huang,Richard Eckner,Shoumo Bhattacharya,C. H. Jiang,M A Goldberg,H. Franklin Bunn,David M. Livingston +7 more
TL;DR: In this article, the intact cDNA for HIF-1α and p300/CBP were cloned and shown to participate in the induction of hypoxia-responsive genes, including vascular endothelial growth factor.
Journal ArticleDOI
Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle
Zoltan Arany,Huamei He,Jiandie D. Lin,Kirsten Hoyer,Christoph Handschin,Okan Toka,Ferhaan Ahmad,Takashi Matsui,Sherry Chin,Pei Hsuan Wu,Igor I. Rybkin,John M. Shelton,Monia Manieri,Saverio Cinti,Frederick J. Schoen,Rhonda S Bassel-Duby,Anthony Rosenzweig,Joanne S. Ingwall,Bruce M. Spiegelman +18 more
TL;DR: Using genetic knockout mice, it is shown that, while PGC-1alpha KO mice appear to retain normal mitochondrial volume in both muscle beds, expression of genes of oxidative phosphorylation is markedly blunted, indicating that P GC-1 alpha is vital for the heart to meet increased demands for ATP and work in response to physiological stimuli.