J
João Lopes Dias
Researcher at University of Cambridge
Publications - 49
Citations - 839
João Lopes Dias is an academic researcher from University of Cambridge. The author has contributed to research in topics: Hamiltonian (quantum mechanics) & Ergodic theory. The author has an hindex of 13, co-authored 48 publications receiving 451 citations. Previous affiliations of João Lopes Dias include University of Lisbon & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Eliza Yankova,Eliza Yankova,Wesley Blackaby,Mark Albertella,Justyna Rak,Justyna Rak,Etienne De Braekeleer,Etienne De Braekeleer,Georgia Tsagkogeorga,Ewa S. Pilka,Demetrios Aspris,Dan Leggate,Alan G. Hendrick,Natalie A. Webster,Byron Andrews,Richard Fosbeary,Patrick Guest,Nerea Irigoyen,Maria Eleftheriou,Malgorzata Gozdecka,João Lopes Dias,Andrew J. Bannister,Binje Vick,Irmela Jeremias,George S. Vassiliou,George S. Vassiliou,Oliver Rausch,Konstantinos Tzelepis,Tony Kouzarides +28 more
TL;DR: In this article, a first-in-class catalytic inhibitor of METTL3 was identified and characterized, and a crystal structure of STM2457 in complex with METTL 3 and METTL14 was presented.
Journal ArticleDOI
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition
Paolo Gallipoli,Paolo Gallipoli,George Giotopoulos,George Giotopoulos,Konstantinos Tzelepis,Ana S. H. Costa,Shabana Vohra,Shabana Vohra,Paula Medina-Perez,Faisal Basheer,Faisal Basheer,Ludovica Marando,Ludovica Marando,Lorena Di Lisio,Lorena Di Lisio,João Lopes Dias,João Lopes Dias,Haiyang Yun,Haiyang Yun,Daniel Sasca,Daniel Sasca,Sarah J. Horton,Sarah J. Horton,George S. Vassiliou,George S. Vassiliou,Christian Frezza,Brian J. P. Huntly,Brian J. P. Huntly +27 more
TL;DR: This work highlights the role of metabolic adaptations as a resistance mechanism to several TKI and suggests glutaminolysis as a therapeutically targetable vulnerability when combined with specific TKI in FLT3ITD and other TK activating mutation-driven leukemias.
Journal ArticleDOI
Multidimensional continued fractions, dynamical renormalization and KAM theory
TL;DR: In this article, the authors describe a simple algorithm based on the dynamics of flows on the homogeneous space of lattices of covolume one for the linearization of vector fields on tori of arbitrary dimension.
Journal ArticleDOI
Generic Dynamics of 4-Dimensional C2 Hamiltonian Systems
Mário Bessa,João Lopes Dias +1 more
TL;DR: In this article, the authors studied the dynamical behaviour of Hamiltonian flows defined on 4-dimensional compact symplectic manifolds and found the existence of a C 2residual set of Hamiltonians for which there is an open mod 0 dense set of regular energy surfaces each either being Anosov or having zero Lyapunov exponents almost everywhere.
Journal ArticleDOI
A normal form theorem for Brjuno skew systems through renormalization
TL;DR: In this article, a dynamical renormalization method for the problem of local reducibility of analytic linear quasi-periodic skew-product flows on T 2 × SL ( 2, R ) was developed.