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Demetrios Aspris
Researcher at Wellcome Trust Sanger Institute
Publications - 8
Citations - 1313
Demetrios Aspris is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Myeloid leukemia & Cancer epigenetics. The author has an hindex of 6, co-authored 8 publications receiving 566 citations.
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Journal ArticleDOI
Promoter-bound METTL3 maintains myeloid leukaemia by m 6 A-dependent translation control
Isaia Barbieri,Konstantinos Tzelepis,Luca Pandolfini,Junwei Shi,Gonzalo Millán-Zambrano,Samuel Robson,Demetrios Aspris,Valentina Migliori,Andrew J. Bannister,Namshik Han,Etienne De Braekeleer,Hannes Ponstingl,Alan G. Hendrick,Christopher R. Vakoc,George S. Vassiliou,Tony Kouzarides +15 more
TL;DR: Together, these data define METTL3 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia.
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Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Eliza Yankova,Eliza Yankova,Wesley Blackaby,Mark Albertella,Justyna Rak,Justyna Rak,Etienne De Braekeleer,Etienne De Braekeleer,Georgia Tsagkogeorga,Ewa S. Pilka,Demetrios Aspris,Dan Leggate,Alan G. Hendrick,Natalie A. Webster,Byron Andrews,Richard Fosbeary,Patrick Guest,Nerea Irigoyen,Maria Eleftheriou,Malgorzata Gozdecka,João Lopes Dias,Andrew J. Bannister,Binje Vick,Irmela Jeremias,George S. Vassiliou,George S. Vassiliou,Oliver Rausch,Konstantinos Tzelepis,Tony Kouzarides +28 more
TL;DR: In this article, a first-in-class catalytic inhibitor of METTL3 was identified and characterized, and a crystal structure of STM2457 in complex with METTL 3 and METTL14 was presented.
Journal ArticleDOI
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Esteban A. Orellana,Esteban A. Orellana,Qi Liu,Qi Liu,Eliza Yankova,Eliza Yankova,Mehdi Pirouz,Mehdi Pirouz,Etienne De Braekeleer,Wen Cai Zhang,Jihoon Lim,Demetrios Aspris,Erdem Sendinc,Dimitrios A. Garyfallos,Dimitrios A. Garyfallos,Muxin Gu,Raja Hussain Ali,Alejandro Gutierrez,Alejandro Gutierrez,Sigitas Mikutis,Gonçalo J. L. Bernardes,Eric S. Fischer,Allan Bradley,George S. Vassiliou,George S. Vassiliou,Frank J. Slack,Frank J. Slack,Konstantinos Tzelepis,Konstantinos Tzelepis,Richard I. Gregory +29 more
TL;DR: In this article, the RNA methyltransferase METTL1 catalyzes N7-methylguanosine (m7G) modification of tRNAs and is associated with poor patient survival.
Journal ArticleDOI
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
Konstantinos Tzelepis,Konstantinos Tzelepis,Etienne De Braekeleer,Demetrios Aspris,Isaia Barbieri,M. S. Vijayabaskar,Wen-Hsin Liu,Malgorzata Gozdecka,Malgorzata Gozdecka,Emmanouil Metzakopian,Hamish D. Toop,Monika Dudek,Samuel Robson,Francisco Hermida-Prado,Yu Hsuen Yang,Roya Babaei-Jadidi,Dimitrios A. Garyfallos,Hannes Ponstingl,João M. L. Dias,Paolo Gallipoli,Michael Seiler,Silvia Buonamici,Binje Vick,Andrew J. Bannister,Roland Rad,Roland Rad,Rab K. Prinjha,John C. Marioni,John C. Marioni,John C. Marioni,Brian J. P. Huntly,Jennifer Batson,Jonathan C. Morris,Cristina Pina,Allan Bradley,Irmela Jeremias,Irmela Jeremias,David O. Bates,Kosuke Yusa,Tony Kouzarides,George S. Vassiliou,George S. Vassiliou +41 more
TL;DR: It is shown that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells.
Journal ArticleDOI
meCLICK-Seq, a Substrate-Hijacking and RNA Degradation Strategy for the Study of RNA Methylation.
Sigitas Mikutis,Muxin Gu,Erdem Sendinc,Madoka E Hazemi,Hannah Kiely-Collins,Demetrios Aspris,George S. Vassiliou,George S. Vassiliou,Yang Shi,Yang Shi,Konstantinos Tzelepis,Konstantinos Tzelepis,Konstantinos Tzelepis,Gonçalo J. L. Bernardes,Gonçalo J. L. Bernardes +14 more
TL;DR: MeCLICK-Seq as discussed by the authors uses click-degraders, small molecules that can be covalently attached to RNA species through click-chemistry and can degrade them, that are akin to ribonucleases.