J
Jocelyne Leclerc
Researcher at French Institute of Health and Medical Research
Publications - 18
Citations - 4612
Jocelyne Leclerc is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: AMPK & AMP-activated protein kinase. The author has an hindex of 16, co-authored 18 publications receiving 4123 citations. Previous affiliations of Jocelyne Leclerc include Centre national de la recherche scientifique & University of Paris.
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Journal ArticleDOI
Cellular and molecular mechanisms of metformin: an overview
Benoit Viollet,Benoit Viollet,Benoit Viollet,Bruno Guigas,Nieves Sanz Garcia,Nieves Sanz Garcia,Nieves Sanz Garcia,Jocelyne Leclerc,Jocelyne Leclerc,Jocelyne Leclerc,Marc Foretz,Marc Foretz,Marc Foretz,Fabrizio Andreelli +13 more
TL;DR: Emerging new therapeutic areas for metformin will be reviewed together with recent findings from pharmacogenetic studies linking genetic variations to drug response, a promising new step towards personalized medicine in the treatment of T2D.
Journal ArticleDOI
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
Marc Foretz,Sophie Hébrard,Jocelyne Leclerc,Elham Zarrinpashneh,Maud Soty,Gilles Mithieux,Kei Sakamoto,Fabrizio Andreelli,Benoit Viollet +8 more
TL;DR: It is found that in mice lacking AMPK in the liver, blood glucose levels were comparable to those in wild-type mice, and the hypoglycemic effect of metformin was maintained, demonstrating that met formin inhibits hepatic gluconeogenesis in an LKB1- and AMPK-independent manner via a decrease in hepatic energy state.
Journal ArticleDOI
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives
Benoit Viollet,Bruno Guigas,Bruno Guigas,Jocelyne Leclerc,Jocelyne Leclerc,Sophie Hébrard,Sophie Hébrard,Louise Lantier,Louise Lantier,Rémi Mounier,Rémi Mounier,Fabrizio Andreelli,Marc Foretz,Marc Foretz +13 more
TL;DR: The identification of AMPK targets in hepatic metabolism should be useful in developing treatments to reverse metabolic abnormalities of type 2 diabetes and the metabolic syndrome.
Journal ArticleDOI
AMPK inhibition in health and disease.
Benoit Viollet,Sandrine Horman,Jocelyne Leclerc,Louise Lantier,Marc Foretz,Marc Billaud,Shailendra Giri,Fabrizio Andreelli +7 more
TL;DR: This review discusses recent findings that support the role and function of AMPK inhibition under physiological and pathological states and discusses the importance of whole body energy homeostasis.
Journal ArticleDOI
Intestinal Gluconeogenesis Is a Key Factor for Early Metabolic Changes after Gastric Bypass but Not after Gastric Lap-Band in Mice
Stéphanie Troy,Maud Soty,Maud Soty,Lara Ribeiro,Laure Laval,Laure Laval,Stéphanie Migrenne,Xavier Fioramonti,Bruno Pillot,Bruno Pillot,Véronique Fauveau,Roberte Aubert,Benoit Viollet,Benoit Viollet,Marc Foretz,Marc Foretz,Jocelyne Leclerc,Jocelyne Leclerc,A. Duchampt,A. Duchampt,Carine Zitoun,Carine Zitoun,Bernard Thorens,Christophe Magnan,Gilles Mithieux,Gilles Mithieux,Fabrizio Andreelli +26 more
TL;DR: Mechanistic evidence is provided that the beneficial effects of the EGA procedure on food intake and glucose homeostasis involve intestinal gluconeogenesis and its detection via a GLUT-2 and hepatoportal sensor pathway.