J
Joel N. Glasgow
Researcher at University of Alabama at Birmingham
Publications - 58
Citations - 1759
Joel N. Glasgow is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Viral vector & Genetic enhancement. The author has an hindex of 26, co-authored 55 publications receiving 1603 citations. Previous affiliations of Joel N. Glasgow include University of Texas Medical Branch.
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Journal ArticleDOI
Transductional targeting of adenovirus vectors for gene therapy.
TL;DR: Advances in Ad targeting are described that are predicated on a fundamental understanding of vector/cell interplay, and strategies by which existing paradigms may be combined with Ad vectors to form advanced delivery vehicles with multiple functions are proposed.
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Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis
Vikram Saini,Bridgette M. Cumming,Loni Guidry,Dirk A. Lamprecht,John H. Adamson,Vineel P. Reddy,Krishna C. Chinta,James H. Mazorodze,Joel N. Glasgow,Melissa Richard-Greenblatt,Anaximandro Gómez-Velasco,Horacio Bach,Yossef Av-Gay,Hyungjin Eoh,Kyu Y. Rhee,Adrie J. C. Steyn +15 more
TL;DR: It is reported that Mtb WhiB3, a 4Fe-4S redox sensor protein, regulates EGT production and maintains bioenergetic homeostasis and that EGT modulates drug sensitivity.
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Transductional and transcriptional targeting of adenovirus for clinical applications.
TL;DR: Adenovirus targeting is described in the context of improving the safety and efficacy of clinical approaches utilizing adenoviral vectors and replication competent oncolytic agents, suggesting a critical linkage between targeted agents and increases in therapeutic utility.
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Identification and characterization of nuclear factor κB binding sites in the murine bcl-x promoter
TL;DR: The hypothesis that NF‐κB can act to enhance Bcl‐XL expression via highly selective interactions, where NF‐kkB binding and bcl‐x promoter activation are dependent on both DNA binding site sequence and NF‐σ subunit composition, is supported.
Journal ArticleDOI
An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery
S J Hedley,Adrian Auf Der Maur,S Hohn,Dominik Escher,Alcide Barberis,Joel N. Glasgow,Joanne T. Douglas,Nikolay Korokhov,David T. Curiel +8 more
TL;DR: It is shown that the scFv employed in this study retains functionality and that stabilizing the targeting molecule, per se, is critical to allow retention of antigen recognition in the adenovirus capsid-incorporated context.